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http://dx.doi.org/10.5658/WOOD.2017.45.3.250

Evaluation of Biological Activity on The Hydrolyzable Tannins of Katsura Tree (Cercidiphyllum japonicum)  

Min, Hee-Jeong (Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University)
Lee, Min-Sung (Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University)
Kim, Young-Kyoon (Department of Forest Products & Biotechnology, Kookmin University)
Bae, Young-Soo (Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University)
Publication Information
Journal of the Korean Wood Science and Technology / v.45, no.3, 2017 , pp. 250-257 More about this Journal
Abstract
Eight hydrolyzable tannin compounds, such as gallic acid (1), methyl gallate (2), kurigalin (3), 1,2,3,6-tetra-O-galloyl-${\beta}$-D-(+)-glucose (4), 1,2,3,4,6-penta-O-galloyl-${\beta}$-D-(+)-glucose (5), 6-m-digalloyl-1,2,3,4,6-penta-O-galloyl-${\beta}$-D-(+)-glucose (6), isocorilagin (7), macabarterin (8), were isolated from the EtOAc and $H_2O$ soluble fractions of Katsura tree (Cercidiphyllum japonicum) leaves, wood and bark. Then antioxidative and anti-inflammatory activity were evaluated on the each isolated compound. The antioxidative test was DPPH radical scavenging activity and all of the isolated compounds indicated much higher antioxidative values compare to the controls, BHT and ${\alpha}$-tocopherol. In the anti-inflammatory test measuring nitric oxide (NO) inhibition activity, methyl gallate, 1,2,3,6-tetra-O-galloyl-${\beta}$-D-glucose and 1,2,3,4,6-penta-O-galloyl-${\beta}$-D-glucose inhibited NO production, and especially, methyl gallate showed high inhibition activity. However, the anti-inflammatory activity of the hydrolyzable tannins did not show positive effect. Based on the above results, the hydrolyzable tannins of katsura tree may be used as one of the natural biomass sources that can substitute with the synthetic antioxidant.
Keywords
Katsura tree (Cercidiphyllum japonicum); hydrolyzable tannins; biological activity; antioxidative activity; anti-inflammatory activity;
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