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http://dx.doi.org/10.5658/WOOD.2012.40.4.276

Antifungal activity of essential oil from Cryptomeria japonica against dermatophytic fungi  

Kim, Seon-Hong (Dept. of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University)
Lee, Su-Yeon (Dept. of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University)
Hong, Chang-Young (Dept. of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University)
Jeong, Han-Seob (Dept. of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University)
Park, Mi-Jin (Korea Forest Research Institute)
Choi, In-Gyu (Dept. of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University)
Publication Information
Journal of the Korean Wood Science and Technology / v.40, no.4, 2012 , pp. 276-286 More about this Journal
Abstract
In this study, the antifungal activity of Cryptomeria japonica essential oil against superficial and allergic fungi, Trichophyton schoenleinii, Trichophyton tonsurans, Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, and Aspergillus fumigatus, was evaluated for determining the potential compound as dermatitis treatment. Minimum Inhibitory Concentration (MIC) measurement, TLC bioassay and agar dilution methods were used for determining the antifungal activity of crude essential oil and its fractions from C. japonica. Also, their major constituents were analyzed by GC/MS. The MICs were below 500 ppm at all superficial fungi, and spot 1 of C. japonica essential oil showed highly effective antifungal activity by TLC bioassay. In antifungal activity by agar dilution methods, crude oil showed high antifungal effect at more than 500 ppm and fraction D was significantly effective at even 100 ppm except for A. fumigatus. The major compounds of spot 1 and fraction D of C. japonica oil determined by GC/MS were elemol, ${\gamma}$-eudesmol, and ${\beta}$-eudesmol, which could be used as atopic dermatitis treatment material.
Keywords
Cryptomeria japonica; essential oil; antifungal activity; superficial fungi; atopic dermatitis;
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