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http://dx.doi.org/10.5658/WOOD.2010.38.2.159

Aldose Reductase Inhibition Effect of PhenolicvCompounds Isolated from Paulownia coreana Bark  

Kim, Jin-Kyu (Institute of Natural Medicine, Hallym University)
Lee, Yeon-Sil (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Lim, Soon-Sung (Institute of Natural Medicine, Hallym University)
Bae, Young-Soo (Department of Forest Biomaterials Engineering, Kangwon National University)
Publication Information
Journal of the Korean Wood Science and Technology / v.38, no.2, 2010 , pp. 159-164 More about this Journal
Abstract
Nine compounds, caffeic acid, naringenin, apigenin, luteolin, kaempferol, verbascoside, isoverbascoside, isocampneoside II, and cistanoside F, were isolated from the EtOAc and n-BuOH fractions of P. coreana bark. The structures of these compounds (1-9) were elucidated by spectroscopic methods and literature data. All the isolates were subjected to in vitro bioassay to evaluate their inhibitory activity against rat lens aldose reductase. Among these, compounds 6 and 8 indicated the significant inhibitory activity on rat lens aldose reductase with $IC_{50}$ values of 2.67 and 5.59 ${\mu}M$, respectively. Especially, The inhibition activity of acteoside was 3.9 times better than that of quercetin as a positive control (10.6 ${\mu}M$). These results suggested that phenylethanoid glycosides are likely to be the potential compounds for the prevention and/or treatment of diabetic complications.
Keywords
Aldose reductase inhibition; Paulownia coreana; phenylpropanoid glycosides; diabetic complications;
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