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Study on the Relationship between the Structure and Antioxidant Activities of Chalcones  

Park, Youngki (Div. Biotechnology, Korea Forest Research Institute)
Lee, Hak-Ju (Div. Wood Chemistry & Microbiology, KFRI)
Lee, Wi Young (Div. Biotechnology, Korea Forest Research Institute)
Ahn, Jin-Kwon (Div. Biotechnology, Korea Forest Research Institute)
Hwang, Byung-Ho (Dept. of Wood Science & Engineering, Kangwon National University)
Publication Information
Journal of the Korean Wood Science and Technology / v.34, no.2, 2006 , pp. 88-94 More about this Journal
Abstract
The purpose of this study is to examine the relationship between antioxidant activities and chemical structures of various chalcones. Twenty-two chalcones were assessed for their radical scavenging activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Of 22 compounds tested, the most active on DPPH radical was 2',4-dihydroxy-3,3'5-trimethoxy-5'-propylchacone (4) (72.6% at 100 ppm). It was followed by 3',4'-dihydroxy-3,4,5-trimethoxy-6'-methylchalcone (6), 2',4,4'-trihydroxy-3-methoxy-5-propenylchalcone (7) and 2',4,4'-trihydroxy-3,5-dimethoxychalcone (13). Based on the results, we concluded that the scavenging activity is controlled by the number and the position of the substitution in the compound.
Keywords
chalcone; antioxidant activity; structure-activity relationships;
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Times Cited By KSCI : 4  (Citation Analysis)
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