Browse > Article
http://dx.doi.org/10.22889/KJP.2022.53.3.138

Effects of Betaone Extract on the Inhibition of Adipocyte Differentiation in High-fat Diet-induced Obesity  

Lee, Yongjin (Department of Pharmacy, Sunchon National University)
Shin, Han-Byeol (Department of Pharmacy, Sunchon National University)
Lee, Mi-Ja (Department of Crop Foundation, National Institute of Crop Science, Rural Development Administration (RDA))
Lee, Mi-Kyung (Department of Food and Nutrition, Sunchon National University)
Son, Young-Jin (Department of Pharmacy, Sunchon National University)
Publication Information
Korean Journal of Pharmacognosy / v.53, no.3, 2022 , pp. 138-144 More about this Journal
Abstract
Obesity is a disease in which an abnormally large amount of fat accumulates in the body. Various diseases such as type 2 diabetes, dyslipidemia, high blood pressure, fatty liver, gallbladder disease, and coronary artery disease are induced. In this study, we investigated the effect of betaone, a type of barley, on obesity suppression. After the betaone extract was treated with 3T3 L1 adipocytes, the effect on adipocyte formation was investigated through Oil Red O staining. It was observed that differentiation was inhibited without affecting the viability of 3T3 L1 adipocytes. The effect of betaone extract on obesity inhibition in a mouse model was investigated. As a result of administering betaone extract after a high-fat diet, it was confirmed that the level of blood sugar and body weight was decreased, and glucose uptake ability was improved in a glucose tolerance test. The formation of mouse adipose tissue was suppressed, and the expression of genes involved in the formation and degradation of obesity in liver tissue was improved. These results suggest that betaone extract is a useful substance for improving obesity and is an excellent material for health functional food.
Keywords
Obesity; Barley extract; Adipocyte differentiation; High-fat; Glucose tolerance test;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Chua, S. C. Jr. (1997) Monogenic models of obesity. Behav. Genet. 27: 277-284.   DOI
2 Flier, J. S. and Maratos, F. E. (1998) Obesity and the hypothalamus: novel peptides for new pathways. Cell 92: 437-440.   DOI
3 Gesta, S., Tseng, Y. H. and Kahn, C. R. (2007) Developmental origin of fat: Tracking obesity to its source. Cell 131: 242-256.   DOI
4 Vetvicka, V. and Vetvickova, J. (2009) Effects of yeast-derived beta-glucans on blood cholesterol and macrophage functionality. J. Immunotoxicol. 6: 30-35.   DOI
5 Brown, G. D. and Gordon, S. (2003) Fungal beta-glucans and mammalian immunity. Immunity 19: 311-315.   DOI
6 Tosh, S. M., Brummer, Y., Wolever, T. M. S. and Wood, P. J. (2008) Glycemic response to oat bran muffins treated to vary molecular weight of β-glucan. Cereal Chemistry 85: 211-217.   DOI
7 Lee, Y., Lee, H.-J., Shin, H. -B., Ham, J. R., Lee, M.-K., Lee, M.-J. and Son, Y.-J. (2022) Triphenyl hexene, an active substance of Betaone barley water extract, inhibits RANKL-induced osteoclast differentiation and LPS-induced osteoporosis. Journal of Functional Foods 92: 105037
8 Kim, H. J., Lee, Y. M., Kim, Y. H., Won, S. I., Choi, S. A. and Choi, S. W. (2009) Inhibition of adipogenesis in 3T3-L1 adipocytes with Magnolia officinalis extracts. J. Soc. Cosmet. Scientists Korea 35: 117-123.
9 Cha, S. Y., Jang, J. Y., Lee, Y. H., Lee, G., Lee, H. J., Hwang, K. T., Kim, Y., Jun, W. and Lee, J. (2010) Lipolytic effect of methanol extracts from Luffa cylindrica in mature 3T3-L1 adipocytes. J. Korean Soc. Food Sci. Nutr. 39: 813-819.   DOI
10 Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C. and Sugiyama, T. (1999) PPARgamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell 4: 597-609.   DOI
11 Jones, J. R., Barrick, C., Kim, K. A., Lindner, J., Blondeau, B., Fujimoto, Y., Shiota, M., Kesterson, R. A., Kahn, B. B. and Magnuson, M. A. (2005) Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 102: 6207-6212.   DOI
12 Wu, Z., Bucher, N. L. and Farmer, S. R. (1996) Indeuction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBP beta, C/EBP delta, and glucocorticoids. Mol. Cell Biol. 16: 4128-4136.   DOI
13 Wu, Z., Xie, Y., Bucher, N. L. and Farmer, S. R. (1995) Conditional etopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev. 9: 2350-2363.   DOI
14 Zhang, J. W., Klemm, D. J., Vinson, C. and Lane, M. D. (2004) Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis. J. Biol. Chem. 279: 4471-4478.   DOI
15 Heck, A. M., Yanovski, J. A. and Calis, K. A. (2000) Orlistat, a new lipase inhibitor for the management of obesity. Pharmacotherapy 20: 270-279.   DOI
16 Despres, J. P. and Lemieux, I. (2006) Abdominal obesity and metabolic syndrome. Nature 444: 881-887.   DOI
17 Kolehmainen, M., Vidal, H., Alhava, E. and Uusitupa, M. I. (2001) Sterol regulatory element binding protein 1c (SREBP-1c) expression in human obesity. Obes. Res. 9: 706-712.   DOI
18 Yang, F., Duan, M., Zheng, F., Yu, L., Wang, Y., Wang, G., Lin, J., Han, S., Gan, D., Meng, Z. and Zhu, S. (2021) Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx. Cancer Lett. 522: 93-104.   DOI
19 Attie, A. D. and Scherer, P. E. (2009) Adipocyte metabolism and obesity. J. Lipid Res. 50: 395-399.   DOI
20 Bae, C. R., Kwon, D. Y. and Cha, Y. S. (2013) Anti-obesity effects of salted and unsalted doenjang supplementation in C57BL/6J mice fed with high fat diet. J. Korean Soc. Food Sci. Nutr. 42: 1036-1042.   DOI
21 Gregoire, F. M., Smas, C. M. and Sul, H. S. (1998) Under-standing adipocyte differentiation. Physiol. Rev. 78: 783-809.   DOI
22 Khoury, D. E. l., Cuda, C., Luhovyy, B. L. and Anderson, G. H. (2012) Beta glucan: health benefits in obesity and metabolic syndrome. J. Nutr. Metab. 2012: 1-28.