Browse > Article
http://dx.doi.org/10.22889/KJP.2022.53.1.16

Diterpene Glycosides from the Aerial Parts of Inula britannica var. chinensis Regel  

Kim, Dae Keun (College of Pharmacy, Woosuk University)
Kim, Jun Hyeong (Department of Food and Biotechnology, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.53, no.1, 2022 , pp. 16-20 More about this Journal
Abstract
Five ent-kaurane type diterpene glycosides were isolated from the aerial parts of Inula britannica var. chinensis Regel (Compositae) through repeated column chromatography. Their chemical structures were elucidated as 16β-H-ent-kauran-19-oic acid-19-O-β-D-glucopyranoside (1), 16β-hydroxy-17-acetoxy-ent-kauran-19-oic acid-19-O-β-D-glucopyranoside (2), 16β,17-dihydroxy-ent-kauran-19-oic acid-19-O-β-D-glucopyranoside (3), 16α,17-dihydroxy-ent-kauran-19-oic acid-19-O-β-D-glucopyranoside (4) and 17-O-β-D-glucopyranosyl-16β-H-ent-kauran-19-oic acid-19-O-β-D-glucopyranoside (5), respectively, by spectroscopic analysis. Among these compounds, 1-4 were isolated for the first time from this plant.
Keywords
Inula britannica var. chinensis; Compositae; ent-kaurane type diterpene glycoside;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Zhou, B.-N., Bai, N.-S., Lin, L.-Z. and Cordell, G. A. (1993) Sesquiterpene lactones from Inula britannica. Phytochemistry 34: 249-252.   DOI
2 Hong, J. Y., Kim, H., Lee, J., Jeon, W. J., Baek, S. H. and Ha, I. H. (2021) Neurotherapeutic effect of Inula britannica var. Chinensis against H2O2-induced oxidative stress and mitochondrial dysfunction in cortical neurons. Antioxidants (Basel). 10: 375.   DOI
3 Je, K. H., Han, A. R., Lee, H. T., Mar, W. and Seo, E. K. (2004) The inhibitory principle of lipopolysaccharide-induced nitric oxide production from Inula britannica var. chinensis. Arch. Pharm. Res. 27: 83-85.   DOI
4 Sung, C. K., Kimura, T., But, P. P. H. and Guo, J.-X. (1998) International Collation of Traditional and Folk Medicine Vol. 3, 568-569, World Scintific, Singapore.
5 Bai, N,. Lai, C. S., He, K., Zhou, Z., Zhang, L., Quan, Z., Zhu, N., Zheng, Q. Y., Pan, M. H. and Ho, C. T. (2006) Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. J. Nat. Prod. 69: 531-535.   DOI
6 Fischedick, J. T., Pesic, M., Podolsi-Renic, A., Bankovic, J., de Vos, R. C. H., Peric, M., Todorovic, S. and Tanic, N. (2013) Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines. Phytochemistry Lett. 6: 246-252.   DOI
7 Shao, Y., Bai, N.-S. and Zhou, B.-N. (1996) Kaurane glycosides from Inula britannica. Phytochemistry 42: 783-786.   DOI
8 Cheng, D.-L., Cao, X.-P., Wei, H.-X. and He, L. (1993) Kaurane diterpenoids from Aster ageratoides. Phytochemistry 33: 1181-1183.   DOI
9 Yan, L., Cheng, X. R., Zeng, Q., Qin, J. J., Zhang, W. D. and Jin, H. Z. (2011) Phytane and neoclerodane diterpenes from the aerial parts of Inula nervosa Wall. Biochem. Syst. Ecol. 39: 700-703.   DOI
10 Yang, L., Wang, X., Hou, A., Zhang, J., Wang, S., Man, W., Yu, H., Zheng, S., Wang, Q., Jiang, H. and Kuang, H. (2021) A review of the botany, traditional uses, phytochemistry, and pharmacology of the Flos Inulae. J. Ethnopharmacol. 276: 114125.   DOI
11 Harinantenaina, L., Kasai, R. and Yamasaki, K (2002) A new ent-kaurane diterpenoid glycoside from the leaves of Cussonia bojeri, a malagasy endemic plant. Chem. Pharm. Bull. 50: 1122-1123.   DOI
12 Lee, Y. N. (2006) New flora of Korea II, 277, Kyo-Hak Publishing Co., LTD, Seoul.