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http://dx.doi.org/10.22889/KJP.2021.52.4.219

Investigation and Risk Characterization on the Contamination Level of Herbal Medicines Without Legal Benzo(a)pyrene Specification  

Park, Young-Ae (Gangbuk Agro-Fishery Products & Herbal Medicine Inspection Center, Seoul Metropolitan Government Research Institute of Public Health and Environment)
Ko, Suk-Kyung (Gangbuk Agro-Fishery Products & Herbal Medicine Inspection Center, Seoul Metropolitan Government Research Institute of Public Health and Environment)
Cho, Seok-Ju (Gangbuk Agro-Fishery Products & Herbal Medicine Inspection Center, Seoul Metropolitan Government Research Institute of Public Health and Environment)
Hwang, In-Sook (Gangbuk Agro-Fishery Products & Herbal Medicine Inspection Center, Seoul Metropolitan Government Research Institute of Public Health and Environment)
Shin, Gi-Young (Gangbuk Agro-Fishery Products & Herbal Medicine Inspection Center, Seoul Metropolitan Government Research Institute of Public Health and Environment)
Moon, Kwang-Deog (School of Food Science and Biotechnology, Kyungpook National University)
Publication Information
Korean Journal of Pharmacognosy / v.52, no.4, 2021 , pp. 219-227 More about this Journal
Abstract
By analysing the benzo(a)pyrene concentration using HPLC-FLD and LC-MS/MS, pollution levels of herbal medicines without permitted benzo(a)pyrene specification were investigated. Average benzo(a)pyrene concentrations were 38.30, 37.46 and 21.22 ㎍/kg for Amomi Tsao-ko Fructus, Mume Fructus and Coptidis Rhizoma, respectively, which are 4 to 7 times higher than maximum permitted benzo(a)pyrene concentration of Rehmanniae Radix Preparata and Rehmanniae Radix, i.e. 5.0 ㎍/kg. Proportion of detected samples exceeding 5.0 ㎍/kg benzo(a)pyrene concentration was 22% for Cimicifugae Rhizoma and Scrophulariae Radix, 44% for Forsythiae Fructus, 67% for Mume Fructus, 100% for Amomi Tsao-ko Fructus and Coptidis Rhizoma, and collectively 29% (36 out of 125 samples) in average. In terms of risk characterization results, human exposure of benzo(a)pyrene were 7.96, 3.49 and 1.61 ng/kg b.w./day and the margin of exposure(MOE) were 1.25 × 104, 2.86 × 104 and 6.20 × 104 for Mume Fructus, Amomi Tsao-ko Fructus and Coptidis Rhizoma, respectively. MOE banding of those herbal medicines was categorized to 'low concern'. However, considering that human exposure of benzo(a)pyrene for food is legislated to 1.4~2.5 ng/kg b.w./day, it was urgent to set up the guideline of benzo(a)pyrene in herbal medicines.
Keywords
Benzo(a)pyrene concentration; Risk characterization; Margin of exposure;
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