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http://dx.doi.org/10.22889/KJP.2021.52.4.203

Structure and Bioactivity of Boholamide A from a Tidal Mudflat Actinomycete  

Seo, Jeongwon (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University)
Moon, Kyuho (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University)
Publication Information
Korean Journal of Pharmacognosy / v.52, no.4, 2021 , pp. 203-207 More about this Journal
Abstract
LC/MS approach targeting secondary metabolites of bacterial strain resulted in the discovery of boholamide A (1), from the culture of marine actinomycete strain which was isolated from a tidal mudflat in Muan, Republic of Korea. Boholamide A (1), a cyclodepsipeptide with HDMN, APD, glycine, and valine was structurally determined by using 1D/2D NMR spectroscopy, mass spectrometry and UV spectroscopy. Boholamide A (1) showed the inhibitory activity against Bacillus subtilis, with IC50 value of 0.08 mM.
Keywords
Bacterial secondary metabolite; Structural determination; Boholamide A; Cyclodepsipeptide; Tidal mudflat;
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1 Prebble, D. W., Holland, D. C., Robertson, L. P., Avery, V. M. and Carroll, A. R. (2020) Citronamine A, an antiplasmodial isoquinoline alkaloid from the australian marine sponge Citronia astra. Org. Lett. 22: 9574-9578.   DOI
2 Torres, J. P., Lin, Z., Fenton, D. S., Leavitt, L. U., Niu, C., Lam, P. Y., Robes, J. M., Peterson, R. T., Concepcion, G. P., Haygood, M. G., Olivera, B. M. and Schmidt, E. W. (2020) Boholamide A, an apd-class, hypoxia-selective cyclodepsipeptide. J. Nat. Prod. 83: 1249-1257.   DOI
3 McBrien, K. D., Berry, R. L., Lowe, S. E., Neddermann, K. M., Bursuker, I., Huang, S., Klohr, S. E. and Leet, J. E. (1995) Rakicidins, new cytotoxic lipopeptides from Micromonospora sp. fermentation, isolation and characterization. J. Antibiot. 48: 1446-1452.   DOI
4 Hamed, I., Ozogul, F., Ozogul, Y. and Regenstein, J. M. (2015) Marine bioactive compounds and their health benefits: a review. Compr. Rev. Food. Sci. F. 14: 446-465.   DOI
5 Lindequist, U. (2016) Marine-derived pharmaceuticals - challenges and opportunities. Biomol. Ther. 24: 561-571.   DOI
6 Hu, Y., Chen, J., Hu, G., Yu, J., Zhu, X., Lin, Y., Chen, S. and Yuan, J. (2015) Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012. Mar. Drugs 13: 202-221.   DOI
7 Guo, Y. W., Liu, X. J., Yuan, J., Li, H. J., Mahmud, T., Hong, M. J., Yu, J. C. and Lan, W. J. (2020) L-tryptophan induces a marine-derived fusarium sp. to produce indole alkaloids with activity against the zika virus. J. Nat. Prod. 83: 3372-3380.   DOI
8 Fangzhi, H., Guangju, L., Xuhai, Z., Yahui, D., Liang, W., Yijing, W., Yue, C., and Quan, Z. (2021) Total synthesis and structure revision of boholamide A. Org. Lett. 23: 4976-4980.   DOI
9 Abdelmohsen, U. R., Szesny, M., Othman, E. M., Schirmeister, T., Grond, S., Stopper, H. and Hentschel, U. (2012) Antioxidant and anti-protease activities of diazepinomicin from the sponge-associated Micromonospora strain RV115. Mar. Drugs 10: 2208-2221.   DOI
10 Demirkiran, O., Almaliti, J., Leao, T., Navarro, G., Byrum, T., Valeriote, F. A., Gerwick, L. and Gerwick, W. H. (2021) Portobelamides A and B and caciqueamide, cytotoxic peptidic natural products from a caldora sp. marine cyanobacterium. J. Nat. Prod. 84: 2081-2093.   DOI
11 Solanki, R., Khanna, M. and Lal, R. (2008) Bioactive compounds from marine actinomycetes. Indian J. Microbiol. 48: 410-431.   DOI
12 Mayer, A. M. and Hamann, M. T. (2005) Marine pharmacology in 2001-2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action. Comp. Biochem. Physiol C. Toxicol. Pharmacol. 140: 265-286.   DOI
13 Subramani, R. and Aalbersberg, W. (2012) Marine actinomycetes: an ongoing source of novel bioactive metabolites. Microbiol. Res. 167: 571-580.   DOI
14 Fenical, W. and Jensen, P. R. (2006) Developing a new resource for drug discovery: marine actinomycete bacteria. Nat. Chem. Biol. 2: 666-673.   DOI
15 Blunt, J. W., Copp, B. R., Keyzers, R. A., Munro, M. H. and Prinsep, M. R. (2012) Marine natural products. Nat. Prod. Rep. 29: 144-222.   DOI