Effects of Black rice (Oryza sativa L.) Aleurone layer on Cyclophosphamide-induced Immunosuppression in Mice
![]() |
Lee, Eun Byeol
(National Institute of Agricultural Sciences, Rural Development Administration)
Choi, Ji-Hye (National Institute of Agricultural Sciences, Rural Development Administration) Kim, Si Hyun (National Institute of Agricultural Sciences, Rural Development Administration) Jang, Hwan Hee (National Institute of Agricultural Sciences, Rural Development Administration) Lee, Sung Hyen (National Institute of Agricultural Sciences, Rural Development Administration) |
1 | Choi, B. K., Nam, S. Y., Lee, Y. M., Kim, J. B., Choe, J. S., Lee, H. J., Lee, S. J. and Lee, S. H. (2015) Supplementary effects of black rice (Oryza sativa L.) Aleurone layer extract on body fat, serum lipid, and serum hormone levels in ovariectomized rats. The Journal of the Korea Contents Association 15: 599-605. DOI |
2 | Lee, E. B., Lee, S. H., Park, Y. G., Choi, J. H., Lee, H. K., Jang, H. H., Hwang, K. A., Choe, J. S., Park, S. Y., Choi, A. J., Hwnag, I. G., Kim, J. S., Lee, H. J., Lee, S. J. and Jeong, H. C. (2019) Platycodon grandiflorum extract ameliorates cyclophosphamide-induced immunosuppression in mice. J. East Asian Soc. Diet. Life 29: 303-309. DOI |
3 | Chen, S., Liu, C., Huang, X., Hu, L., Huang, Y., Chen, H., Fang, Q., Dong, N., Li, M., Tang, W. and Nie, S. (2020) Comparison of immunomodulatory effects of three polysaccharide fractions from Lentinula edodes water extracts. J. Funct. Foods 66: 103791. DOI |
4 | Byun, E. H. (2015) Comparison study of immunomodulatory activity of polysaccharide and ethanol extracted from Sargassum fulvellum. J. Korean Soc. Food Sci. Nutr. 44: 1621-1628. DOI |
5 | Yang, L. C., Hsieh, C. C. and Lin, W. C. (2015) Characterization and immunomodulatory activity of rice hull polysaccharides. Carbohydr. Polym. 124: 150-156. DOI |
6 | Choi, J. P., Kim, Y. S., Kim, O. Y., Kim, Y. M., Jeon, S. G., Roh, T. Y., Park, Y. S. and Kim, Y. K. (2012) TNF-alpha is a key mediator in the development of T h2 cell response to inhaled allergens induced by a viral PAMP double-stranded RNA. Allergy 67: 1138-1148. DOI |
7 | Hussain, A., Shadma, W., Maksood, A. and Ansari, S. H. (2013) Protective effects of Picrorhiza kurroa on cyclophosphamide-induced immunosuppression in mice. Pharmacognosy Res. 5: 30. DOI |
8 | Cerutti, A., Chen, K. and Chorny, A. (2011). Immunoglobulin responses at the mucosal interface. Annu. Rev. Immunol. 29: 273-293. DOI |
9 | Yoo, H. J., You, D. J. and Lee, K. W. (2019) Characterization and immunomodulatory effects of high molecular weight fucoidan fraction from the sporophyll of Undaria pinnatifida in cyclophosphamide-induced immunosuppressed mice. Mar. drugs 17: 447. DOI |
10 | Wang, Y., Qi, Q., Li, A., Yang, M., Huang, W., Xu, H., Zhao, Z. and Li, S. (2016) Immuno-enhancement effects of Yifei Tongluo Granules on cyclophosphamide-induced immunosuppression in Balb/c mice. J. Ethnopharmacol. 194: 72-82. DOI |
11 | Shirani, K., Hassani, F. V., Razavi-Azarkhiavi, K., Heidari, S., Zanjani, B. R. and Karimi, G. (2015) Phytotrapy of cyclophosphamide-induced immunosuppression. Environ. Toxicol. Pharmacol. 39: 1262-1275. DOI |
12 | Dowell, A. C., Oldham, K. A., Bhatt, R. I., Lee, S. P. and Searle, P. F. (2012) Long-term proliferation of functional human NK cells, with conversion of CD56 dim NK cells to a CD56 bright phenotype, induced by carcinoma cells coexpressing 4-1BBL and IL-12. Cancer Immunol. Immunother. 61: 615-628. DOI |
13 | Yu, F., Zhang, Z., Ye, S., Hong, X., Jin, H., Huang, F., Yang, Z., Tang, Y., Chen, Y. and Ding, G. (2019) Immunoenhancement effects of pentadecapeptide derived from Cyclina sinensis on immune-deficient mice induced by Cyclophosphamide. J. Funct. Foods 60: 103408. DOI |
14 | Gonzalez-Rey, E., Chorny, A. and Delgado, M. (2007) Regulation of immune tolerance by anti-inflammatory neuropeptides. Nat. Rev. Immunol. 7: 52-63. DOI |
15 | World Health Organization. (2020). International guidelines for certification and classification (coding) of COVID-19 as cause of death. International Statistical Classification of Diseases. |
16 | Sujono, T. A., Kusumowati, I. T. D. and Munawaroh, R. (2021) Effects of Jamaican cherry (Muntingia calabura L.) Fruits Extract on Immunoglobulin G Levels and Hematological Profiles in Mice. Pharmacogn. J. 13: 535-541. |
17 | Ilangkovan, M., Jantan, I., Mesaik, M. A. and Bukhari, S. N. A. (2015) Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats. Drug Des. Devel. Ther. 9: 4917. DOI |
18 | Cheng, D., Wan, Z., Zhang, X., Li, J., Li, H. and Wang, C. (2017) Dietary Chlorella vulgaris ameliorates altered immunomodulatory functions in cyclophosphamide-induced immunosuppressive mice. Nutrients. 9: 708. DOI |
19 | Lee, S. B., Cha, J., Kim, I. K., Yoon, J. C., Lee, H. J., Park, S. W., Cho, S. J., Youn, D. Y., Lee, H. J., Lee, C. H., Lee, J. M., Lee, K. Y. and Kim, J. S. (2014) A high-throughput assay of NK cell activity in whole blood and its clinical application. Biochem. Biophys. Res. Commun. 445: 584-590. DOI |
20 | Yu, Y., Song, Q., Huang, L., Shen, M., Yu, Q., Chen, Y. and Xie, J. (2020) Immunomodulatory activities of sulfated Cyclocarya paliurus polysaccharides with different degrees of substitution on mouse spleen lymphocytes. J. Funct. Foods 64: 103706. DOI |
21 | Zhang, M. W., Zhang, R. F., Zhang, F. X. and Liu, R. H. (2010) Phenolic profiles and antioxidant activity of black rice bran of different commercially available varieties. J. Agric. Food Chem. 58: 7580-7587. DOI |
22 | Zhou, Y., Chen, X., Yi, R., Li, G., Sun, P., Qian, Y. and Zhao, X. (2018) Immunomodulatory effect of tremella polysaccharides against cyclophosphamide-induced immunosuppression in mice. Molecules 23: 239. DOI |
23 | Korean Statistical Information Service. (2020) Food grain consumption survey. Statistics Korea. |
24 | Lee, H. M., Im, J. S., Park, J. D., Kum, J. S., Lee, H. Y. and Lee, Y. T. (2013) Amylolytic activity of brown rice and black rice during germination. J. Food Sci. Technol. 45: 333-338. |
25 | Kong, S., Kim, D. J., Oh, S. K., Choi, I. S., Jeong, H. S. and Lee, J. (2012) Black rice bran as an ingredient in noodles: chemical and functional evaluation. J. Food Sci. 77: C303-C307. DOI |
26 | Kim, H. J., Park, H. Y., Kim, M. Y., Lee, J. Y., Lee, J. H., Lee, J. Y., Lee, B. W., Kim, M. and Lee, B. (2021) Physicochemical characteristics of brown rice porridge added with colored rice cultivars. JKFN 50: 279-284. DOI |
27 | Min, S. W., Ryu, S. N. and Kim, D. H. (2010) Anti-inflammatory effects of black rice, cyanidin-3-O-β-D-glycoside, and its metabolites, cyanidin and protocatechuic acid. Int. Immunopharmacol. 10: 959-966. DOI |
28 | Chen, P. N., Kuo, W. H., Chiang, C. L., Chiou, H. L., Hsieh, Y. S. and Chu, S. C. (2006) Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. Chem. Biol. Interact. 163: 218-229. DOI |
29 | Min, B., McClung, A. M. and Chen, M. H. (2011) Phytochemicals and antioxidant capacities in rice brans of different color. J. Food Sci. 76: C117-C126. DOI |
30 | Martin-F., a, A., Thomsen, L. L., Brett, S., Gerard, C., Lipp, M., Lanzavecchia, A. and Sallusto, F. (2004) Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH 1 priming. Nat. Immunol. 5: 1260-1265. DOI |
31 | Lee, M. K., Ryu, S. I. and Lee, M. H. (2018) Improvement of anti-oxidant and anti-inflammatory activities of aleurone layer extracts of black rice (Oryza sativa L.) by enzyme treatment. J. Food. Sci. Technol. 50: 528-534. DOI |
32 | Wang, H., Xu, L., Yu, M., Wang, Y., Jiang, T., Yang, S. and Lv, Z. (2019) Glycosaminoglycan from Apostichopus japonicus induces immunomodulatory activity in cyclophosphamide-treated mice and in macrophages. Int. J. Biol. Macromol. 130: 229-237. DOI |
33 | Shin, H. Y., Kim, S. M., Lee, J. H. and Lim, S. T. (2019) Solid-state fermentation of black rice bran with Aspergillus awamori and Aspergillus oryzae: Effects on phenolic acid composition and antioxidant activity of bran extracts. Food Chem. 272: 235-241. DOI |
34 | Marieb, E. N. (1998) Human anatomy and Physiology, Fourth edition, Benjamin / Cummings Publishing Co. California. 612-617, 723-725. |
![]() |