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http://dx.doi.org/10.22889/KJP.2021.52.3.134

The Effect of 1,9-Dihydroxycrenulide and Epiloliolide from Dictyota coriacea on the Hair Growth  

Kang, Jung-Il (Jeju Research Center for Natural Medicine, Jeju National University)
Oh, Tae Heon (Department of Chemistry & Cosmetics, Jeju National University)
Kim, Jioh (Department of Medicine, School of Medicine, Jeju National University)
No, Haemin (Department of Medicine, School of Medicine, Jeju National University)
Lee, Nam Ho (Department of Chemistry & Cosmetics, Jeju National University)
Yoo, Eun-Sook (Jeju Research Center for Natural Medicine, Jeju National University)
Kang, Hee-Kyoung (Jeju Research Center for Natural Medicine, Jeju National University)
Publication Information
Korean Journal of Pharmacognosy / v.52, no.3, 2021 , pp. 134-142 More about this Journal
Abstract
This study was conducted to evaluate the effects of Dictyota coriacea extract and its active components such as 1,9-dihydroxycrenulide and epiloliolide on the hair growth. Treatment with D. coriacea extract and the hexane and EtOAc fractions of D. coriacea extract significantly increased the proliferation of dermal papilla cells (DPCs), a central regulator of the hair cycle. Especially, 1,9-dihydroxycrenulide and epiloliolide from D. coriacea extract, caused an increase in the DPC proliferation. When isolated rat vibrissa follicles were treated with 1,9-dihydroxycrenulide or epiloliolide for 21 d, the hair-fiber lengths for the vibrissa follicles increased. When examined the activity of 5α-reductase, which converts testosterone to dihydrotestosterone (DHT), a main cause of androgenetic alopecia, the several solvent fractions of D. coriacea extract significantly decreased the 5α-reductase activity while 1,9-dihydroxycrenulide and epiloliolide scarcely inhibited 5α-reductase activity. In addition, we found that the D. coriacea extract and several solvent fractions of D. coriacea extract could not act as a KATP channel opener, which could be a contributory factor in the effect on hair growth. These results suggest that D. coriacea extract and 1,9-dihydroxycrenulide and epiloliolide, principals of D. coriacea, have the potential to treat alopecia via the proliferation of DPCs.
Keywords
Dictyota coriacea; 1,9-Dihydroxycrenulide; Epiloliolide; Hair growth; Dermal papilla cells;
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