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http://dx.doi.org/10.22889/KJP.2021.52.2.92

Biological Activity of Fermented Gryllus bimaculatus extracts  

Park, In-Sun (Jeonju AgroBio-Materials Institute(JAMI))
Lim, Hyeon-Ji (Jeonju AgroBio-Materials Institute(JAMI))
Jeong, Seung-Il (Jeonju AgroBio-Materials Institute(JAMI))
Jung, Chan-Hun (Jeonju AgroBio-Materials Institute(JAMI))
Publication Information
Korean Journal of Pharmacognosy / v.52, no.2, 2021 , pp. 92-98 More about this Journal
Abstract
Gryllus bimaculatus extract (GbE) have reported that anti-inflammatory activity by suppression of pro-inflammatory cytokines. However, the effects of fermented Gryllus bimaculatus extract (FGbE) have not yet been investigated. In this study, we evaluated the anti-inflammatory and anti-wrinkle effect of the fermented Gryllus bimaculatus extracts using Bacillus subtilis (JB PMB-18) in RAW264.7 cells. Both GbE and FGbE exerted no cytotoxic effects until 1000 ㎍/mL concentration. FGbE decreased NO production and decreased iNOS and COX-2 mRNA levels in a concentration-dependent manner. In addition, the protein production of inflammatory cytokines TNF-α, IL-1β and IL-6 was effectively reduced compared to the GbE. Inhibitory activities of elastase and collagenase associated with skin wrinkle improvement were measured to be 45% and 69%, respectively, at a concentration of 500 ㎍/mL in FGbE. From these results, FGbE can be used as a health functional food and skin functional cosmetic materials for preventing inflammatory diseases because it has excellent anti-inflammatory and anti-wrinkle effects.
Keywords
Gryllus bimaculatus; Gryllidae; Fermentation; Anti-inflammatory; Anti-wrinkle; Cosmetic materials;
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