Browse > Article
http://dx.doi.org/10.22889/KJP.2021.52.1.55

Belamcandae Rhizoma Extract Improves Memory Impairment in Mice  

Jung, Ji Wook (Division of Bio-technology and Convergence, Daegu Haany University)
Publication Information
Korean Journal of Pharmacognosy / v.52, no.1, 2021 , pp. 55-60 More about this Journal
Abstract
Belamcandae Rhizoma (BR), the rhizome of Belamcanda chinensis (L.) DC., possesses various biological properties such as anti-inflammatory activity, antioxidant activity and antimutagenic activity. However, there have been no studies on the anti-amnesic effect of BR. In this study, we assessed the improvement effect of BR extract on scopolamine-induced amnesia in mice. ICR mice were administrated with BR (50, 100 or 200 mg/kg, p.o.) and were subsequently injected of scopolamine (1 mg/kg, i.p.) 30 min before behavioral tasks (Y-maze, passive avoidance and Morris water maze tasks). To further assess the possible mechanisms of BR, the ex vivo acetylcholinesterase (AChE) activity was also evaluated. BR could ameliorate scopolamine-induced memory impairment and could regulate the cholinergic function by inhibiting the AChE activity. These data demonstrated that BR exert candidate extract against amnesia by restoring the cholinergic activity.
Keywords
Belamcanda chinensis; Belamcandae Rhizoma; Scopolamine; Memory; Dementia;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Lee, J. W., Lee, C., Jin, Q., Lee, M. S., Kim, Y., Hong, J. T., Lee, M. K. and Hwang, B. Y. (2015) Chemical constituents from Belamcanda chinensis and their inhibitory effects on nitric oxide production in RAW 264.7 macrophage cells. Arch. Pharm. Res. 38: 991-997.   DOI
2 Ellman, G. L., Courtney, K. D., Andres Jr, V. and Featherstone, R. M. (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology 7: 88-95.   DOI
3 Wozniak, D. and Matkowski, A. (2015) Belamcandae chinensis rhizome--a review of phytochemistry and bioactivity. Fitoterapia 107: 1-14.   DOI
4 Gao, X., Xu, D., Zhang, X. and Zhao, H. (2020) Protective effect of lemon peel polyphenols on oxidative stress-induced damage to human keratinocyte HaCaT cells through activation of the Nrf2/HO-1 signaling pathway. Front. Nutr. 7: 606776.
5 Hazafa, A., Rehman, K. U., Jahan, N. and Jabeen, Z. (2020) The role of polyphenol (flavonoids) compounds in the treatment of cancer cells. Nutr. Cancer. 72: 386-397.   DOI
6 Joseph, S. V., Edirisinghe, I. and Burton-Freeman, B. M. (2016) Fruit polyphenols: A review of anti-inflammatory effects in humans. Crit. Rev. Food Sci. Nutr. 56: 419-444.   DOI
7 Witte, A. V., Kerti, L., Margulies, D. S. and Floel, A. (2014) Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J. Neurosci. 34: 7862-7870.   DOI
8 Moore, A., Beidler, J. and Hong, M. Y. (2018) Resveratrol and depression in animal models: A systematic review of the biological mechanisms. Molecules 23: 2197.   DOI
9 Liu, T., Ma, Y., Zhang, R., Zhong, H., Wang, L., Zhao, J., Yang, L. and Fan, X. (2019) Resveratrol ameliorates estrogen deficiency-induced depression- and anxiety-like behaviors and hippocampal inflammation in mice. Psychopharmacology (Berl) 236: 1385-1399.   DOI
10 Siddique, F., Abbas, R. Z., Mansoor, M. K., Alghamdi, E. S., Saeed, M., Ayaz, M. M., Rahman, M., Mahmood, M. S., Iqbal, A., Manzoor, M., Abbas, A., Javaid, A. and Hussain, I. (2020) An insight into COVID-19: A 21st century disaster and its relation to immunocompetence and food antioxidants. Front. Vet. Sci. 7: 586637.
11 Jeong, G., An, R., Oh, S., Kang, D., Lee, H. and Kim, Y. (2007) Cytoprotective activity of Belamcanda chinensis Rhizome against glutamate-induced oxidative injury in HT22 cells. Nat. Prod. Sci. 13: 101-104.
12 임혜진 (2007) Neuroprotective effect of tectoridin and tectorigenin from Belamcanda chinensis in cell culture systems. 석사학위논문, 서울대학교; 서울: 2007.
13 Slusarczyk, S., Senol Deniz, F. S., Wozniak, D., Pecio, L., Perez-Sanchez, H., Ceron-Carrasco, J. P., Stochmal, A., den-Haan Alonso, H., Matkowski, A. and Orhan, I. E. (2019) Selective in vitro and in silico cholinesterase inhibitory activity of isoflavones and stilbenes from Belamcandae chinensis rhizoma. Phytochemistry Letters 30: 261-272.   DOI
14 Marucci, G., Buccioni, M., Ben, D. D., Lambertucci, C., Volpini, R. and Amenta, F. (2020) Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease. Neuropharmacology 6: 108352.
15 Tang, K. S. (2019) The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers. Life Sci. 233: 116695.   DOI
16 Takahashi, T. (2021) Multiple roles for cholinergic signaling from the perspective of stem cell function. Int. J. Mol. Sci. 22: 666.   DOI
17 Ballinger, E. C., Ananth, M., Talmage, D. A. and Role, L. W. (2016) Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline. Neuron. 91: 1199-1218.   DOI
18 Drevets, W. C., Bhattacharya, A. and Furey, M. L. (2020) The antidepressant efficacy of the muscarinic antagonist scopolamine: Past findings and future directions. Adv. Pharmacol. 89: 357-386.   DOI
19 Brinza, I., Boiangiu, R. S., Hancianu, M., Cioanca, O., Erdogan Orhan, I. and Hritcu, L. (2021) Bay leaf (Laurus nobilis L.) incense improved scopolamine-induced amnesic rats by restoring cholinergic dysfunction and brain antioxidant status. Antioxidants (Basel) 10: 259.   DOI
20 Boiangiu, R. S., Mihasan, M., Gorgan, D. L., Stache, B. A. and Hritcu, L. (2021) Anxiolytic, promnesic, anti-acetylcholinesterase and antioxidant effects of cotinine and 6-hydroxy-L-nicotine in scopolamine-induced zebrafish (Danio rerio) model of Alzheimer's disease. Antioxidants (Basel) 10: 212.   DOI
21 Noh, D., Choi, J. G., Lee, Y. B., Jang, Y. P. and Oh, M. S. (2019) Protective effects of Belamcandae Rhizoma against skin damage by ameliorating ultraviolet-B-induced apoptosis and collagen degradation in keratinocytes. Environ. Toxicol. 34: 1354-1362.   DOI
22 Baek, S. Y., Li, F. Y., Kim, J. H., Ahn, C., Kim, H. J. and Kim, M. R. (2020) Protein hydrolysate of silkworm pupa prevents memory impairment induced by oxidative stress in scopolamine-induced mice via modulating the cholinergic nervous system and antioxidant defense system. Prev. Nutr. Food Sci. 25: 389-399.   DOI
23 MEDICLASSICS [homepage on the Internet]. Korea Institute of Oriental Medicine; 2015 [cited 2 Feb 2021]. Available from: https://mediclassics.kr/books/190/volume/22#content_426.
24 한국한의학연구원. 오선(烏扇). 특허청; 2007.
25 Park, S. J. and Kim, S. K. (2010) Anti-inflammatory effects of Belamcanda Chinensis water extract. Korean J. Oriental Physiology & Pathology 24: 410-415.
26 Kim, D.-S., Sung, B.-G., Lee, J.-C., Lee, B.-K., Woo, W.-H. and Lim, K.-S. (2011) Inhibitory effect of Belamcandae Rhizoma on the melanogenesis in MSH-stimulated B16F10 cells. J. Korean Med. Ophthalmol. Otolaryngol. Dermatol. 24: 25-35.   DOI
27 Li, S., Li, S., Tang, Y., Liu, C., Chen, L. and Zhang, Y. (2016) Ultrafiltration-LC-MS combined with semi-preparative HPLC for the simultaneous screening and isolation of lactate dehydrogenase inhibitors from Belamcanda chinensis. J. Sep. Sci. 39: 4533-4543.   DOI
28 Liu, E. Y., Zheng, Z. X., Zheng, B. Z., Xia, Y., Guo, M. S., Dong, T. T. and Tsim, K. W. K. (2020) Tectorigenin, an isoflavone aglycone from the rhizome of Belamcanda chinensis, induces neuronal expression of erythropoietin via accumulation of hypoxia-inducible factor-1alpha. Phytother. Res. 34: 1329-1337.   DOI