Determination of Silymarin and Silybin Diastereomers in Korean Milk Thistle using HPLC/UV Analysis |
Kim, Juree
(Department of Plant Science and Technology, Chung-Ang University)
Paje, Leo Adrianne (Department of Plant Science and Technology, Chung-Ang University) Choi, Jung Won (Department of Plant Science and Technology, Chung-Ang University) Lee, Hak-Dong (Department of Plant Science and Technology, Chung-Ang University) Shim, Jae Suk (Imsil Herbal Medicine Association) Shim, Jeehyoung (EL&I Co., Ltd.) Geraldino, Paul John L. (Department of Biology, University of San Carlos) Lee, Sanghyun (Department of Plant Science and Technology, Chung-Ang University) |
1 | Rose, F. (1981) The Wild Flower Key: A Guide to Plant Identification in the Field with and without Flowers. Frederoc Warne/Penguin Group, London. |
2 | Basiglio, C. L., Pozzi, E. J. S., Mottino, A. D. and Roma, M. G. (2009) Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis. Chem. Biol. Interact. 179: 297-303. DOI |
3 | Wagner, H., Seligmann, O., Seitz, M., Abraham, D. and Sonnenbichler, J. (1976) Silydianin und Silychristin, zwei isomere Silymarine aus Silybum marianum L. Gaertn. (Mariendistel). Z. Naturforsch B 31: 876-884. DOI |
4 | Bhattacharya, S. (2011) Phytotherapeutic properties of milk thistle seeds: An overview. J. Adv. Pharm. Educ. Res. 1: 69-79. |
5 | Schumann, J., Prock, J., Kiemer, A. K., Vollmar, A. M., Bang, R. and Tiegs, G. (2003) Silibinin protects mice from T cell-dependent liver injury. J. Hepatol. 39: 333-340. DOI |
6 | Feher, J. and Lengyel, G. (2012) Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr. Pharm. Biotechnol. 13: 210-217. DOI |
7 | KOksal, E., GULCIN, I., Beyza, S., Sarikaya, O. and Bursal, E. (2009) In vitro antioxidant activity of silymarin. J. Enzyme Inhibit. Med. Chem. 24: 395-405. DOI |
8 | Yoo, I.-D., Choo, S.-J., Ryoo, I.-J., Kim, Y.-H., Xu, G.-H., Kim, K.-H., Han, C.-S., Kim, S.-J., Kim, J.-W. and Son, E.-D. (2009) Hypopigmentary effect of milk thistle extract silymarin. J. Soc. Cosmet. Scientists Korea 35: 151-158. |
9 | Guo, H., Cao, H., Cui, X., Zheng, W., Wang, S., Yu, J. and Chen, Z. (2019) Silymarin's inhibition and treatment effects for Alzheimer's disease. Molecules 24: 1748. DOI |
10 | Lee, D. Y. W., and Liu, Y. Z. (2003) Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, isolated from Silybum marianum (milk thistle). J. Nat. Prod. 66: 1171-1174. DOI |
11 | Kvasnicka, F., Biba, B., Sevcik, R., Voldrich, M. and Kratka, J. (2003) Analysis of the active components of silymarin. J. Chromatogr. A 990: 239-245. DOI |
12 | Abenavoli, L., Capasso, R., Milic, N. and Capasso, F. (2010) Milk thistle in liver diseases: past, present, future. Phytother. Res. 24: 1423-1432. DOI |
13 | Serviddio, G., Bellanti, F., Stanca, E., Lunetti, P., Blonda, M., Tamborra, R., Siculella, L., Vendemiale, G., Capobianco, L. and Giudetti, A. M. (2014) Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis. Free Radic. Biol. Med. 73: 117-126. DOI |
14 | Trappoliere, M., Caligiuri, A., Schmid, M., Bertolani, C., Failli, P., Vizzutti, F., Novo, E., di Manzano, C., Marra, F., Loguercio, C. and Pinzani, M. (2009) Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells. J. Hepatol. 50: 1102-1111. DOI |
15 | Song, Z., Deaciuc, I., Song, M., Lee, D. Y.‐W., Liu, Y., Ji, X. and McClain, C. (2006) Silymarin protects against acute ethanol‐induced hepatotoxicity in mice. Alcohol Clin. Exp. Res. 30: 407-413. DOI |
16 | Tayoub, G., Sulaiman, H. and ALorfi, M. (2018) Quantitative identification of total silymarin in wild Silybum marianum L. by using HPLC. Int. J. Herb. Med. 6: 110-114. |
17 | Sohrabi, M. J., Dehpour, A. R., Attar, F., Hasan, A., Mohammad-Sadeghi, N., Meratan, A. A., Aziz, F. M., Salihi, A., Shekha, M. S., Akhtari, K., Shahpasand, K., Hojjati, S. M. M., Sharifi, M., Saboury, A. A., Rezayat, S. M., Mousavi, S. E. and Falahati, M. (2019) Silymarin-albumin nanoplex: Preparation and its potential application as an antioxidant in nervous system in vitro and in vivo. Int. J. Pharm. 572: 118824. DOI |
18 | Karimi, G., Vahabzadeh, M., Lari, P., Rashedinia, M. and Moshiri, M. (2011) Silymarin, a promising pharmacological agent for treatment of diseases. Iran. J. Basic Med. Sci. 14: 308-317. |
19 | Saller, R., Melzer, J., Reichling, J., Brignoli, R. and Meier, R. (2007) An updated systematic review of the pharmacology of silymarin. Forsch Komplementmed 14: 70-80. |
20 | Radjabian, T., Rezazadeh, S. H. and Fallah Huseini, H. (2008) Analysis of silymarin components in the seed extracts of some milk thistle ecotypes from Iran by HPLC. Iran. J. Sci. Technol. Trans A 32: 141-146. |
21 | Rodriguez, J. P., Quilantang, N. G., Lee, J. S., Lee, J. M., Kim, H. Y., Shim, J. S. and Lee, S. (2018) Determination of silybin B in the different parts of Silybum marianum using HPLC-UV. Nat. Prod. Sci. 24: 82-87. DOI |
22 | Zhang M, Chen K, Hu Z, Shen Q, Wang H. (2018) PRiME pass-through purification of lignans in Silybum marianum and UPLC-MS/MS analysis. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1093-1094: 128-133. DOI |