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http://dx.doi.org/10.22889/KJP.2020.51.4.278

Evaluation of Clinical Usefulness of Herbal Mixture HO-Series for Improving Hangover  

Chang, Bo Yoon (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
Bae, Jin Hye (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
Kim, Da Eun (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
Kim, Dae Sung (HanpoongPharm. CO., Ltd)
Cho, Hyoung Kwon (HanpoongPharm. CO., Ltd)
Kim, Sung Yeon (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
Publication Information
Korean Journal of Pharmacognosy / v.51, no.4, 2020 , pp. 278-290 More about this Journal
Abstract
The purpose of this study is to investigate the hangover relieving effect of HO-series. HO-S1 is an herbal mixture, which consists of extracts from Flower of Pueraria lobata Ohwi, Glycyrrhiza glabra Linné, Fruit of Lycium chinense Miller, Poria cocos Wolf, Acanthopanax sessiliflorum Seeman, Scutellaria baicalensis Georgi, Atractylodes lancea De Candlle and Zingiber officinale Roscoe. HO-S2 is a candidate that has been performed to ultra filtration based on HO-S1. HO-S3 is a mixture of amino acids and vitamins based on HO-S2. HO-01 is the final beverage base produced based on HO-S3. The antioxidant activity of HO-series was similar to that of vitamin C or trolox. The production of t-BHP induced reactive oxygen species(ROS) was significantly blocked in the presence of HO-series. In vivo study, AUC of alcohol and acetaldehyde concentrations in HO-S2 and HO-S3 treated groups significantly decreased. Hepatic alcohol dehydrogenase(ADH) and acetaldehyde dehydrogenase(ALDH) activity were significantly higher in HO-S2 and HO-S3 treated groups. And 2E1 activity and glutathione were significantly elevated, while the malondialdehyde level was not significantly in liver tissue. After alcohol exposure, the sensitivity scores of blood alcohol and acetaldehyde concentration and hangover symptoms were significantly decreased in the HO-01 intake group compared with the non-intake group. ALDH activity was significantly increased in the HO-01 intake group. HO-series have antioxidant activity and a protective effect from ROS. HO-S2, HO-S3 and HO-01 are potentially highly beneficial in relieving hangover, as it scavenges reactive free radicals and boosts the endogenous antioxidant system.
Keywords
HO-series; Herbal Mixture; Hangover; Hepatoprotective; Antioxidant;
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Times Cited By KSCI : 3  (Citation Analysis)
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