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http://dx.doi.org/10.22889/KJP.2020.51.3.186

Anti-nociceptive Effects of Sorbus alnifolia  

Kim, Bong Seok (College of Pharmacy, Woosuk University)
Yun, Sun Hwa (College of Pharmacy, Woosuk University)
Shin, Youn Chel (College of Pharmacy, Woosuk University)
Kang, Bo Hye (College of Pharmacy, Woosuk University)
Park, Seung Ju (College of Pharmacy, Woosuk University)
Yang, Woo In (College of Pharmacy, Woosuk University)
Lee, Se Youn (College of Pharmacy, Woosuk University)
Cha, Dong Seok (College of Pharmacy, Woosuk University)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.51, no.3, 2020 , pp. 186-191 More about this Journal
Abstract
In this study, we evaluated the anti-nociceptive activities of Sorbus alnifolia. To investigate the anti-nociceptive properties of the methanolic extract of Sorbus alnifolia (MSA), we conducted several tests using various experimental mouse pain models. Herein, MSA significantly delayed the latency time and writhing motion in the hotplate test and acetic acid test, respectively. These result indicated that MSA has an ability to manage both peripheral and central nociception. We could further confirm the analgesic effects of MSA by performing formalin test. In combination test using naloxone, a non-selective opioid receptor antagonist, analgesic activity of MSA was partly antagonized by naloxone, but not completely, indicating that the MSA acts as a partial opioid receptor agonist. Out results suggest that the S. alnifolia may be possibly used as valuable anti-nociceptive agent.
Keywords
Sorbus alnifolia; Anti-nociception; Opioid receptor;
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