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http://dx.doi.org/10.22889/KJP.2020.51.2.122

Anti-inflammatory Effect of Herbal Complex HP-04 on Degenerative Osteoarthritis  

Jo, Hyoung-Kwon (Central Research and Development, Hanpoong Pharm & Foods)
Kim, Dae-Sung (Central Research and Development, Hanpoong Pharm & Foods)
Kim, Jung-Young (Department of Food and Drug, Chosun University Graduate School)
Park, Young-Mi (INVIVO Co. Ltd.)
Shin, Dong-Yeop (INVIVO Co. Ltd.)
Lee, Hak-Yong (INVIVO Co. Ltd.)
Kim, Hoon (Department of Pharmaceutics & Biotechnology, Konyang University)
Lee, Dong-Sung (Department of Food and Drug, Chosun University Graduate School)
Cho, Seong-Wan (Department of Pharmaceutics & Biotechnology, Konyang University)
Publication Information
Korean Journal of Pharmacognosy / v.51, no.2, 2020 , pp. 122-130 More about this Journal
Abstract
To investigate the anti-inflammatory effect on Degenerative Osteoarthritis, Male sprague-Dawley rats were randomized and classified into three different concentration groups. We measured weekly weight change, dietary intake, drinking water intake, blood analysis like TNF-α (tumor necrosis factor-α), IL-6 (interleukin 6), TIMP-1 (tissue inhibitor of metalloprotease-1), MMP-2 (matrix metalloprotease-2), MMP-9 (matrix metalloprotease-9) and micro CT analysis. The results suggest that the treatment with herbal complex HP-04 improved the Monosodium iodoacetate (MIA) induced degenerative osteoarthritis and it could be applicable for the improvement of arthritic symptoms as a new therapeutic agent.
Keywords
Osteoarthritis; Monosodium iodoacetate; Herbal complex HP-04; TNF; IL-6; MMP-2;
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