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http://dx.doi.org/10.22889/KJP.2020.51.1.036

Cancer Cell Growth Inhibition of Lanostane-type Triterpenoids Isolated from Ganoderma gibbosum  

Kim, Donghwa (College of Pharmacy, Seoul National University)
Lee, Sang Kook (College of Pharmacy, Seoul National University)
Park, Hee-Juhn (Department of Pharmaceutical Engineering, Sangji University)
Publication Information
Korean Journal of Pharmacognosy / v.51, no.1, 2020 , pp. 36-40 More about this Journal
Abstract
The CHCl3 fraction of the MeOH extract of Ganoderma gibbosum (Ganodermataceae) exhibited cytotoxic activity on five cancer cell lines (MDA-MB-231, SK-hep1, A549, HCT116, and SNU638). Six highly oxygenated lanostane-type triterpenoids (lanostanoids) were isolated by column chromatography to test cytotoxicity on cancer cells. The five known lanostanoids were identified as gibbosic acids A, B, D, G, and H by comparison of molecular ion peaks with the literature data. The structure of a new lanostanoid, gibbosic acids I, was identified to be 3β,8β,15β,20S-tetrahydroxy-7,12,23-trioxolanost-9(11)-en-26-oic acid on the basis of NMR and MS spectroscopy. The three lanostanoids of gibbosic acids A, H, and I of the six isolates significantly suppressed the growth of cancer cells. In particular, the IC50 of gibbosic acid H was prominently low ranging from 2.64-6.56 μM.
Keywords
Ganoderma gibbosum; Ganodermataceae; Lanostanoids; Gibbosic acids; Cytotoxicity;
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