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http://dx.doi.org/10.22889/KJP.2020.51.1.030

Neuroprotective Activity of Caffeic Acid Isolated from Lonicera japonica  

Son, Yerim (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Ma, Choong Je (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Publication Information
Korean Journal of Pharmacognosy / v.51, no.1, 2020 , pp. 30-35 More about this Journal
Abstract
We previously reported that caffeic acid isolated from Lonicera japonica showed potent neuroprotective activities against glutamate injured neuronal cell death in primary cortical cells. In this study, we tried to confirm the neuroprotective activity in glutamate injured HT22 cells and elucidate mechanisms of neuroprotective action of caffeic acid. We used glutamate induced HT22 cell death as a bioassay system. The compound decreased reactive oxygen species increased by high concentration of glutamate treatment in HT22 cells. Also, Ca2+ concentration was decreased by this compound. This compound made mitochondrial membrane potential maintain to normal condition. This also affected anti-oxidative enzymes and glutathione contents. Treatment of this compound increased not only glutathione reductase and peroxidase to the control level and also amount of glutathione, an endogeneous antioxidant. These experimental results showed that caffeic acid isolated from L. japonica exerted potent neuroprotective activity through the anti-oxidative pathway.
Keywords
Lonicera japonica; Caffeic acid; Neuroprotection; Antioxidant; Alzheimer's disease;
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