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Secondary Metabolites Isolated from Ganoderma lucidum and Their Anti-inflammatory Activity  

Kim, Hye Ji (Unit of Polar Genomics, Korea Polar Research Institute, KIOST)
Koo, Man Hyung (Unit of Polar Genomics, Korea Polar Research Institute, KIOST)
Lee, Jun Hyuck (Unit of Polar Genomics, Korea Polar Research Institute, KIOST)
Suh, Sung-Suk (Department of Life Sciences, Mokpo National University)
Youn, Ui Joung (Department of Polar Sciences, University of Science and Technology)
Publication Information
Korean Journal of Pharmacognosy / v.50, no.3, 2019 , pp. 232-238 More about this Journal
Abstract
Phytochemical study of Ganoderma lucidum (Polyporaceae) let to the isolation of five lanostane triterpenoid (1-5), along with two nitrogen derived phenolic compounds, N-phenylethylformamide (6) and N-acetylphenethylamine (7). The structures of the compounds were determined by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with published values. Compounds 6 and 7 were isolated for the first time from the genus Ganoderma and this species. All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Among the isolates, compounds 2 and 3 showed moderate inhibitory activity against NO production.
Keywords
Ganoderma lucidum; Polyporaceae; Lanstane triterpenoid; Anti-inflammatory;
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