Aged Doraji (Platycodon grandiflorum) Ameliorates Cyclophosphamide-Induced Immunosuppression in Mice |
Choi, Ji-Hye
(National Institute of Agricultural Sciences, Rural Development Administration)
Lee, Eun Byeol (National Institute of Agricultural Sciences, Rural Development Administration) Park, Yang-Gyu (National Institute of Agricultural Sciences, Rural Development Administration) Lee, Hye Kyung (National Institute of Agricultural Sciences, Rural Development Administration) Jang, Hwan Hee (National Institute of Agricultural Sciences, Rural Development Administration) Choe, Jeongsook (National Institute of Agricultural Sciences, Rural Development Administration) Hwang, Kyung-A (National Institute of Agricultural Sciences, Rural Development Administration) Park, Shin Young (National Institute of Agricultural Sciences, Rural Development Administration) Hwang, In Guk (National Institute of Agricultural Sciences, Rural Development Administration) Hong, Ha Cheol (National Institute of Agricultural Sciences, Rural Development Administration) Lee, Hae-Jeung (Department of Food and Nutrition, Gachon University) Jeong, Hyun Cheol (Food R&D Center, SK bioland Co. Ltd.) Kim, Hyun-Ju (World Institute of Kimchi) Lee, Sung Hyen (National Institute of Agricultural Sciences, Rural Development Administration) |
1 | Lee, H. J., Seung, Y. C. and Lee, M. S. (2018) Immune regulation effects of Gentianae Radix extract in LPS-induced acute inflammatory mice. Kor. J. Herbol. 33: 79-84. |
2 | Huh, S. H. (2014) Health functional food market trends and consumer survey. Korea Health Supplements Association, Korea Seongnam. |
3 | KHSA (2016) Health functional food market trends and consumer survey, 142-144, Korea Health Supplements Association, Korea Seongnam. |
4 | Yu, A. R., Park, H. Y., Kim, Y. S., Ha, S. K., Hong, H. D. and Choi, H. D. (2012) Immuno-enhancing effect of seed extracts on a RAW 264.7 macrophage cell line. J. Korean Soc. Food Sci. Nutr. 41: 1671-1676. DOI |
5 | Hyun, S. H., Kim, Y. S., Lee, J. W., Han, C. K., Seon, P. M. and So, S. H. (2018) Immunomodulatory effects of argininefructose-glucose enriched extracts of red ginseng. J. Korea Soc. Food Sic. Nutr. 47: 1-6. DOI |
6 | Sung, N. J., Lee, S. J., Shin, J. H., Lee, J. S. and Chung, Y. H. (1996) Effects of Platycodon grandiflorum extract on blood glucose and lipid composition in alloxan Induced Hyperhglycemic Rats. J. Korean Soc. Food Sci. Nutr. 25: 986-992. |
7 | Chung, J. H., Shin, P. G., Ryu, J. C., Jang, D. S. and Cho, S. H. (1997) Chemical compositions of Platycodon grandiflorus( jacquin). A De. Candolle Agric. Chem. Biotechnol. 40: 148-151. |
8 | Shon, M. Y., Seo, J. K., Kim, H. J. and Sung, N. J. (2001) Chemical compositions and physiological activities of doraji (Platycodon grandiflorum). J. Korean Soc. Food Sci. Nutr. 30: 717-720. |
9 | Hong, M. W. (1974) Statistical analyeses of Platycodi Radix prescriptions. Kor. J. Pharmacog. 5: 61-67. |
10 | Konishi, T., Tada, A., Shoji, J., Kasai, R. and Tanaka, O. (1976) The structures of platycodin A and C, monoacetylated saponins of the roots of Platycodon grandiflorum A. DC. Chem. Pharm. Bull. 26: 668-670. DOI |
11 | Tada, A., Kaneiwa, Y., Shoji, J. and Shibata, S. (1975) Studies on the saponins of the root of Platycodon grandiflorum A. DE CANDOLLE. I. isolation and the structure of platycodin-D. Chem. Pharm. Bull. 23: 2965-2969. DOI |
12 | Kim, S. Y., Lee, E. B. and Jeong, E. J. (2012) Anti-inflammatory components of Platycodi Radix butanol fractions. J. East Asian Soc. Dietary Life 22: 772-781. |
13 | Kwon, O. J., Lee, S. W., Paik, S. H., Han, S. R., Ahn, Y. M., Ahn, S. Y. and Lee, B. C. (2013) The effects of Platycodi Radix on obese type 2 diabetes mouse model induced by high fat, high carbohydrate diet. J. Korean Oriental Med. 34: 1-14. |
14 | Choung, M. G. and Shon, E. H. (2011) Anti-tumor activity of saponin fraction of Platycodon grandiflorum through immunomodulatory effects associated with NO production in RAW264.7 cells. Korean J. Plant Res. 24: 557-563. DOI |
15 | Lee, S. W., Kim, K. T. and Ko H. (2011) Effects of the water extract of cultivated wild ginseng on the toxicities induced by cyclophosphamide in mice. Korean J. Oriental Physiology & Pathology 25: 849-856. |
16 | Park, S. E., Lee, S. Y., Shin, D. Y., Jeong, J. W., Jin, M. H., Park, S. Y., Chung, Y. H., Hwang, H. J., Hong, S. H. and Choi, Y. H. (2013) Pro-apoptotic effects of platycodin D isolated form Platycodon grandiflorum in human leukemia Cells. J. Life Sci. 23: 389-398. DOI |
17 | Lee, Y. S., Lee, G. H., Kwon, Y. K., Park, J. H. and Shin, S. W. (2007) Immunomodulatory effect of aqueous extracted Zingiberis Rhizoma on cyclophosphamide - induced immune suppression. Korean J. Oriental Physiology & Pathology 21: 485-490 |
18 | Lee, Y. S., Lee, G. H., Park, J. H., Kwon, Y. K. and Shin, S. W. (2007) Water extracted Evodiae Fructus Possesses immunomodulatory activities on cyclophosphamide induced immunesuppression. Korean J. Physiology & Pathology 21: 1450-1455. |
19 | Jeong, D. Y., Yang, H. J., Jeong, S. J., Kim, M. G., Yun, C. Y., Lee, H. Y., Lee, Y. H., Shin, D. Y., Yang, Y. G., Lee, H. S. and Park, Y. M. (2019) Immunostimulatory effects of blueberry yeast fermented powder against cyclophosphamideinduced immunosuppressed model. J. Physiol & Pathnol. Korean Med. 33: 48-55. DOI |
20 | Kim, E. H., Gwak, J. Y. and Jung, M. J. (2018) Immunomodulatory activity of Platycodon grandiflorum, Codonopsis lanceolata, and Adenophora triphylla extracts in macrophage cells. J. Korean Soc. Food Sci. Nutr. 47: 1069-1075. DOI |
21 | Ryu, H. S., Kim, K. O. and Kim, H. S. (2009) Effects of plant water extract Codonopsis Lanceolatae on mouse immune cell activation Ex vivo. Korean J. Nutr. 42: 207-212. DOI |
22 | Ryu, H. S. (2014) Effects of water extract from Platycodon grandiflorum on mouse immune cell activation ex vivo by oral administration. Korean J. Food & Nutr. 27: 99-104. DOI |
23 | Kim, H. S., Chung, K. T., Lee, I. H., Choi, W. B., Lee, J. H., Hyun, S. K., Kim, B. W. and Hwang, H. J. (2014) Effect of Alpina Officinarum ethanol extract on immunoregulatory activities in the mice. J. Life Sci. 24: 61-66. DOI |
24 | Lee, E. B., Lee, S. H., Park, Y. G., Choi, J. H., Lee, H. K., Jang, H. H., Hwang, K. A., Choe, J. S., Park, S. Y., Choi, A. J., Hwnag, I. G., Kim, J. S., Lee, H. J., Lee, S. J. and Jeong, H. C. (2019) Platycodon grandiflorum extract ameliorates cyclohphosphamide-induced immunosuppression in mice. J. East Asian Soc. Dietary Life 29: 303-309. DOI |
25 | Park, E. J., Lee, Y. S., Jeong, H. C., Lee, S. H. and Lee, H. J. (2019) Mitigation effects of red Platycodon grandiflorum extract on lipopolysaccharide-induced inflammation in splenocytes isolated from mice. J. Nutr. Health 52: 243-249. DOI |
26 | Lee, S. H., Jang, H. H., Choe, J. S., Hwang, K. A., Kim, J. B., Choi, A. J., Im, P. R., Jeon, G. M., Lee, E. B., Choi, J. H., Park, S. Y., Lee, S. J. and Jeong, H. C. (2018) 10-0162372, A composition for improving immunity comprising an effective ingredient of red balloon flower extract having improved safety and immunity improving ability. |
27 | Kang, B. B., Kim, C. Y., Hwang, J. S. and Choi, H. S. (2019) Non-saponin fraction of red ginseng inhibits monocyte-tomacrophage differentiation and inflammatory responses in vitro. Korean J. Food Sci. Technol. 51: 70-80. DOI |
28 | Koo, S. W., Lim, M. K. and Lee, K. W. (2015) Immunomodulatory effects of Zingiber officinale in cyclophosphamide-induced immunosuppress mice. J. Vet. Clin. 32: 56-61. DOI |
29 | Miyauchi, A. Hiramine, C., Tanaka, S. and Hojo, K. (1990) Differential effects of a single dose of cyclophosphamide on T cell subsets of the thymus and spleen in mice: flow cytofluorometry analysis. Tohoku J. Exp. Med. 162: 147-167. DOI |
30 | Xun, C. Q., Thornpson, J. S., Jennings, C. D., Brown, S. A. and Widrner, M. B. (1994) Effects of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graftversus-host disease in H-2-incompatible transplanted SCID mice. Blook. 83: 2360-2367. |
31 | Chun, E. Y. (1997) Partial purification of Hottuynia cordata Thunb extract and characterization of its immunological activites in human. MS Thesis, Seoul National University, Korea Seoul. |
32 | Hyun, S. H., Kim, E. S., Lee, S. M., Kyung, J. S., Lee, S. M., Lee, J. W., Kim, M. R., Hong, J. T. and Kim, Y. S. (2014) Comparative study on immune-enhancing effects of red ginseng fractions. J. Korean Soc. Food Sci. Nutr. 43: 1665-673. DOI |
33 | Lee, I. H., Kwon, D. H., Lee, S. H., Lee, S. D., Kim, D. W., Lee, J. H., Hyun, S. K., Kang, K. H., Kim, C. M., Kim, B. W., Hwang, H. J. and Chung, K. T. (2014) Immune-modulation effect of Ulmus macrocarpa hance water extract on BALB/c mice. J. Life Sci. 24: 1151-1156. DOI |
34 | Artym. J., Zimecki, M. and Kruzel, M. (2004) Normalization of peripheral blood cell composition by lactoferrin in cyclophosphamide-treated mice. Med. Sci. Monit. 10: 84-89. |
35 | Kim, J., Ryu, H. S., Shin, J. H. and Kim, H. S. (2005) In vitro and ex vivo supplementation of Houttuynia cordata extract and immunomodulation effect in mice. J. Korean Soc. Food Sci. Nutr. 34: 167-175. DOI |
36 | Wu, D., Pae, M., Ren, Z., Guo, Z., Smith, D. and Meydani, S. N. (2007) dietary supplementation with white nutton mushroom enhances natural killer cell activity in C57BL/6 mice. J. Nutr. 137: 1472-1477. DOI |
37 | Kim, Y. H., Kwon, H. S., Kim, D. H., Park, I. H., Park, S. J., Shin, H. K. and Kim, J. K. (2008) Immunomodulatory effects of propolis and fermented-propolis in BALB/c mice. Korean J. Food Sci. Technol. 40: 574-579. |
38 | Vivier, E., Nunes, J. A. and Vely, F. (2004) Natural killer cell signaling pathway. Science 306: 1517-1519. DOI |