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Anti-inflammatory Effect of Eucommia Ulmoides Oliver Bark Extract on P.gingivalis LPS-induced YD-38 Cells  

Kim, Ye-Jin (Laboratory of Life Science Research, Korea Kolmar Corporation)
Heo, Woong (Laboratory of Life Science Research, Korea Kolmar Corporation)
Choi, Han-Seok (Laboratory of Life Science Research, Korea Kolmar Corporation)
Kang, Ki Sung (College of Korean Medicine, Gachon University)
Hwang, Gwi Seo (College of Korean Medicine, Gachon University)
Baek, Ji Yun (Department of Food Science, Gyeongnam National University of Science and Technology)
Koo, Bon Am (Laboratory of Life Science Research, Korea Kolmar Corporation)
Kim, Hyun Young (Department of Food Science, Gyeongnam National University of Science and Technology)
Publication Information
Korean Journal of Pharmacognosy / v.50, no.3, 2019 , pp. 185-190 More about this Journal
Abstract
Periodontitis is a chronic inflammatory disease and gums pull away from the teeth and form spaces. The main goal of treatment is to control the infection and anti-inflammation. Eucommia ulmoides Oliv. Bark (EU) is a traditional Korean herbal used for the treatment of arthritis and hypertension. In the present study, we investigated the anti-inflammatory properties of EU in Porphyromonas gingivalis-LPS (LPS-PG) induced YD-38 epithelial cells. We observed significant inhibition of nitric oxide (NO) production and the expression of interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor alpha ($TNF-{\alpha}$), cyclooxygenase-2 (COX-2) in LPS-PG-induced YD-38 cells. These results support that EU has an anti-inflammatory effects for the treatment of periodontitis.
Keywords
Periodontitis; Eucommia ulmoides oliv. bark (EU); Anti-inflammation; Porphyromonas gingivalis-lps (LPS-PG); YD-38 cells;
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Times Cited By KSCI : 1  (Citation Analysis)
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