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Antioxidant and antidiabetic effects of leaves and stems of Acanthopanax sieboldianum (Makino) Koidz  

Kim, Sang-Jun (Jeonju AgroBio-materials Institute)
Kim, Ji-Ae (Jeonju AgroBio-materials Institute)
Kim, Sol (Jeonju AgroBio-materials Institute)
Youn, Jong-Ung (Agricultural corporation eouidang Co., Ltd.)
Kim, Seok Hong (Korea Testing & Research Institute)
Han, Sang-Sub (Department of Forest Environmental Science, Chonbuk National University)
Kim, Seon-Young (Jeonju AgroBio-materials Institute)
Jeong, Seung-Il (Jeonju AgroBio-materials Institute)
Publication Information
Korean Journal of Pharmacognosy / v.50, no.2, 2019 , pp. 141-147 More about this Journal
Abstract
The aim of this study was to investigate the potential of Acanthopanax sieboldianum (Makino) Koidz (ACS) as a potent antioxidant and antidiabetic agent. The antioxidative and alpha-glucosidase inhibitory activities were examined using the methanol extracts and solvent fractions from ACS-leaf and ACS-stem. Antioxidative activities were measured by in vitro methods such as DPPH and ABTS radical scavenging activity and superoxide dismutase (SOD) activity. When the chloroform and ethyl acetate fractions of ACS-leaf and ethyl acetate fractions of ACS-stem were compared with the control, the SOD-like activity was impaired even at the low treatment concentrations. In addition, the ethyl acetate fractions of ACS-leaf and ACS-stem showed alpha-glucosidase inhibition activities at low treatment concentrations. Analysis of the major components in the fractions of ACS-leaf and ACS-stem was also performed using HPLC. Finally, astragalin, isoqurecetin, chlorogenic acid and caffeic acid contents were measured. Based on this work, we propose that ACS-leaf and ACS-stem have great potential as natural antioxidant and antidiabetic materials related to health benefits.
Keywords
Acanthopanax sieboldianum (Makino) Koidz; Diabetes mellitus; alpha-Glucosidase; Antioxidant;
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