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Anti-obesity Effect of Vegetable Formula on Obese Mice in High Fat Diet  

Lee, Jae-Hyeok (Department of Emergency Medical Rescue, Nambu University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Park, Jeong-Sook (Department of Nursing, Nambu University)
Publication Information
Korean Journal of Pharmacognosy / v.50, no.1, 2019 , pp. 46-52 More about this Journal
Abstract
This study was conducted to investigate the cholesterol and Triglyceride (TG) lowering and anti-obesity effects of water extract of vegetable formula (onion 25%, carrot 20%, Cabbage 20%, Sweet Pumpkins 20%, Chinese plum 5%, turmeric 5%, morus leaves 5%, SLS) in mice fed high fat-diet. ICR mice were divided into 3 groups; a normal diet group (ND), a high-fat diet group (HFD), a high-fat diet and SLS with 300 mg/kg treated group (HFD+SLS). Body fat gain was increased by high-fat diet and HFD+SLS group showed a definite weight loss. The total cholesterol level in the HFD+SLS group was 328.4 mg/dl which was 27.4% lower than that in the HFD group and the cholesterol-lowering effect of SLS was confirmed. The HFD + SLS group showed 118.1 mg/dl and the triglyceride level in the serum was decreased by 88.7% compared to the HFD group and SLS significantly decreased blood triglyceride levels. RT-PCR showed that the expression of PPAR-${\gamma}$ and the target gene SCD-1 was inhibited in a dose-dependent manner in the SLS-treated group. These results suggest that the SLS water extract may have a cholesterol and triglyceride-lowering effect and inhibit the expression of PPAR-${\gamma}$ and SCD-1 to have an anti-obesity effect.
Keywords
Obesity; Vegetable formula; PPAR-${\gamma}$; SCD-1; Cholesterol; Triglyceride;
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