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Antioxidant and Hepatoprotective Effects of the Ethanol Extract of Dendropanax morbifera Leveille on the t-Butyl Hydroperoxide-Induced HepG2 Cell Damages  

Lee, Changyong (College of Pharmacy, Pusan National University)
Yang, Minhye (College of Pharmacy, Pusan National University)
Moon, Jeon-Ok (College of Pharmacy, Pusan National University)
Publication Information
Korean Journal of Pharmacognosy / v.50, no.1, 2019 , pp. 32-36 More about this Journal
Abstract
Dendropanax morbifera Leveille, an endemic species in Korea, is best known as a tree that produces a resinous sap. Although D. morbifera is used in folk medicine for various diseases, its active ingredients are largely unknown. In this study, we investigated antioxidative activities of ethanolic extracts of three parts of this plant including leaves, debarked stems, and roots. The root extracts exhibited strong 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity compared with leaf or stem extracts. The root extracts showed hepatoprotective activity against t-butyl hydroperoxide-induced HepG2 cells, and reduced the ROS level in the cells. The root fractions lowered the mRNA level of COX-2 on lipopolysaccharide-stimulated Raw246.7 cells. These results suggest that ethanolic root extracts of D. morbifera are a source of antioxidant and hepatoprotective compounds, which indicate a potential for a botanical drug.
Keywords
Dendropanax morbifera; Hepatoprotective activity; Antioxidant activity;
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