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Inhibitory Effect of Sparassis crispa (Wulf.) Extract on Monosodium Iodoacetate Induced Osteoarthritis  

Kim, Eun-Nam (College of Pharmacy, Keimyung University)
Roh, Seong-Soo (Department of Herbology, Daegu Haany University)
Jeong, Gil-Saeng (College of Pharmacy, Keimyung University)
Publication Information
Korean Journal of Pharmacognosy / v.49, no.3, 2018 , pp. 262-269 More about this Journal
Abstract
Sparassis crispa (Wulf.) is an edible/medicinal mushroom and has been reported to biological activities such as antitumor, anti-angiogenesis, antioxidant and wound healing. However, there have not been many researches on osteoarthritis of S. crispa. The aim of this study was to investigate the effects of S. crispa extract on rats with osteoarthritis induced by MIA. Osteoarthritis is a gradually developmental disease that early stage, causes joint stiffness and complains of joint pain. In addition, it gives rise to edema and hypo-function. The results of this study, S. crispa extract effectively inhibited ROS production, increased the production of antioxidant protein SOD and catalase in knee joint cartilage tissue. In addition, S. crispa extract inhibited the expression of pro-inflammatory cytokines and enzymes such as NOX4 and $P47^{phox}$, which are involved in the expression of COX-2, iNOS and the production of ROS. Also, S. crispa extract inhibited the destruction of synovial tissue, cartilage tissue and proteoglycans in articular cartilage in rats.
Keywords
Sparassis crispa (Wulf.); MIA (monosodium iodoacetate); Osteoarthritis; ROS (reactive oxygen species);
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1 Takac, I., Schroder, K. and Zhang, L. (2011) The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase NOX4. J. Biol. Chem. 286: 13304-13313.   DOI
2 Filippin, L. I., Vercelino, R., Marroni, N. P. and Xavier, R. M. (2008) Redox signalling and the inflammatory response in rheumatoid arthritis. Am. J. Clin. Exp. Immunol. 152: 415-422.   DOI
3 Hitchonand, C. A. and El-Gabalawy, H. S. (2004) Oxidation in rheumatoid arthritis. Arthritis Res. Ther. 6: 265-278.   DOI
4 Biemond, P., Swaak, A. J. and Koster, J. F. (1984) Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid. Arthritis Rheum. 27: 760-765.   DOI
5 Park, S. H., Lee, H. J., Ryu, J. H., Lee. S. Y., Shin, H. D., Hong, J. H., Seok, J. H. and Lee, C. J. (2014) Effects of Silibinin and Resveratrol on Degradation of I B and Translocation of NF-${\kappa}B$ p65 Induced by Tumor Necrosis Factor-${\alpha}$ in Cultured Airway Epithelial Cells. J. Pharm. 58: 1-6.
6 Asagiri, M. and Takayanagi, H. (2007) The molecular understanding of osteoclast differentiation. Bone. 40: 251-264.   DOI
7 Nelson, A. R., Fingleton, B., Rothenberg, M. L. and Matrisian, L. M. (2000) Matrix metalloproteinases: biolobic activity ans clinical implication. J. Clin. Oncol. 18: 1135-1149.   DOI
8 Zeng, Z. S., Cohen, A. M. and Guillem, J. G. (1999) Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis. Carcinogenesis. 20: 749-755.   DOI
9 Nagasa, H. and Woessner, J. F. (1999) Matrix metalloproteinases. J. Biol. Chem. 274: 21491-21494.   DOI
10 Kim, M. Y., Seguin, P., Ahn, J. K., Kim, J. J., Chun, S. C., Kim, E. H., Seo, S. H., Kang, E. Y., Kim, S. L. and Park, Y. J. (2008) Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea. J. Agr. Food Chem. 56: 7265-7270.   DOI
11 Wasser, S. P. and Weiss, A. L. (1999) Medicinal properties of substances occurring in higher basidomycetes mushrooms: current perspectives. Int. J. Med. Mushrooms. 1: 31-62.   DOI
12 Lee, S. Y., Koo, J. M., Yoo, H. S., Kim, Y. H., Kim, J. W., Lee, J. H., Hong, H. J, Kim, H. I., Park, S. K., Lee, S. W., Chung, W. T., Yoo. Y. H. and Huh, G. Y. (2008) The expression of TRAIL and its receptors in human osteoarthritic cartilages. Int. Medicine. 74: 296-304.
13 Johnston, S. A. (1997) Joint Anatomy, Physiology, and Pathobiology. Vet. Clin. North Am. Small Anim. Pract. 27: 699-723.   DOI
14 Xia, B., Di, C., Zhang, J., Hu, S., Jin, H. and Tong, P. (2014) Osteoarthritis pathogenesis: a review of molecular mechanisms Calcif. Tissue Int. 95: 495-505.   DOI
15 Yang, D. H., Woo, C. H., Kim, J. M. and An, H. D. (2015) Effects of Danggwisayeok-tang (Dangguisinitang) on MIAinduced osteoarthritis rats. J. Korean Med. Rehabi. 25: 33-37.
16 Goldring, S. R. (2003) Inflammatory mediators as essential elements in bone remodeling. Calcif. Tissue Int. 73: 97-100.   DOI
17 Wu, W., Wan, X., Shah, F., Fahad, S. and Huang, J. (2014) The role of antioxidant enzymes in adaptive responses to sheath blight infestation under different fertilization rates and hill densities. Sci. World J. 2014: 502134.
18 Combe, R., Bramwell, S. and Field, M. J. (2004) The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats. Neurosci. Lett. 370: 236-240.   DOI
19 Guzman, R. E., Evans, M. G., Bove, S., Morenko, B. and Kilgore, K. (2003) Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicol. Pathol. 31: 619-624.   DOI
20 Yoon, C. H. (2012) Osteoarthritis Update. Korean J. Intern. Med. 82: 170-174.   DOI
21 Henrotin, Y., Kurz, B. and Aigner, T. (2005) Oxygen and reactive oxygen species in cartilage degradation: friends or foes. Osteoarthritis Cartilage 13: 643-654.   DOI
22 Kurz, B., Lemke, A. and Kehn, M. (2004) Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis Rheum. 50: 123-130.   DOI
23 Kirk, P. M., Cannon, P. F., David, J. C. and Stalpers, J. A. (2003) Ainsworth & Bisby's Dictionary of the Fungi. Lichenologist. 35: 365-366.   DOI
24 Oh, D. S., Park, J. M., Park, H., Ka, K. H. and Chun, W. J. (2009) Site characteristics and vegetation structure of the habitat of cauliflower mushroom (Sparassis crispa). Korean J. Mycol. 37: 33-40.   DOI
25 Radermacher, K. A., Wingler, K., Kleikers, P., Altenhofer, S., Hermans, J. J., Kleinschnitz, C. and Hhw, S. H. (2012) The 1027th target candidate in stroke: Will NADPH oxidase hold up. Exp. Transl. Stroke Med. 4: 1-11.   DOI
26 Babior, B. M. (2004) NADPH oxidase. Curr. Opin. Immunol. 16: 42-47.   DOI