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Skin Safety Evaluation of Pectin Lyase-modified Red Ginseng Extract (GS-E3D)  

Pyo, Mi Kyung (International Ginseng & Herb Research Institute)
Lee, Gyeong Hee (International Ginseng & Herb Research Institute)
Cha, Seon Woo (International Ginseng & Herb Research Institute)
Park, Ki Young (SEWHA P&C Co., Ltd.)
Lee, Ki Moo (SEWHA P&C Co., Ltd.)
Publication Information
Korean Journal of Pharmacognosy / v.49, no.3, 2018 , pp. 246-254 More about this Journal
Abstract
Pectin lyase-modified red ginseng extract (GS-E3D) is a newly developed ginsenoside Rd-enriched ginseng extract. This study was designed to investigate the skin safety of GS-E3D. Single oral toxicity, single dermal toxicity, bovine corneal opacity and permeability (BCOP) assay, skin irritation test with $SkinEthic^{TM}$ human epidermis model, skin sensitization local lymph node assay, and human patch test, were examined. The oral and dermal $LD_{50}$ value of GS-E3D was over 2,000 mg/kg in rats. GS-E3D was identified as a non-irritant to skin in BCOP assay, human epidermis models, and patch test from the 32 human subjects. The skin sensitization potential of GS-E3D was less than 25% in local lymph node assay. These results indicate that GS-E3D can be used as a safe ingredient without adverse effects in various skin care products.
Keywords
GS-E3D; Panax ginseng; Safety; Skin irritation; Human patch test;
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