Browse > Article

Anti-hypertensive Effects of DHP1501, Ethanolic Extracts from Eleutherococcus sessiliflorus Fruits, via Inhibition of Angiotensin Converting Enzyme and Activation of Endothelial Nitric Oxide Synthase  

Kim, Haneul (Daehwa Pharmaceutical Co., Ltd.)
Kim, Hye Min (Daehwa Pharmaceutical Co., Ltd.)
Jang, Jun Hee (Daehwa Pharmaceutical Co., Ltd.)
Yoon, Koung Eun (Daehwa Pharmaceutical Co., Ltd.)
Lee, Yeong-Geun (Graduate School of Biotechnology, Kyung Hee University)
Back, Nam-In (Graduate School of Biotechnology, Kyung Hee University)
Lee, Dae Young (Department of Herbal Crop Research, NIHHS, RDA)
Jung, In Ho (Daehwa Pharmaceutical Co., Ltd.)
Publication Information
Korean Journal of Pharmacognosy / v.49, no.3, 2018 , pp. 240-245 More about this Journal
Abstract
The fruits of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu (Araliaceae), as edible fruits, were traditionally used for ingredients of wine or tea in Eastern Asia. In addition to, the fruits of E. sessiliflorus were known for having antioxidant and anti-inflammatory effects. Recently, we investigated that the ethanolic extracts of E. sessiliflorus fruits (DHP1501) have effects on hypertension via vasorelaxation and decrease of blood pressure. In the present study, we investigated that the gene and protein expression levels of endothelial nitric oxide synthase (eNOS) was increased by treatment of DHP1501 in HUVECs. Moreover, we confirmed the angiotensin converting enzyme inhibitory activity of DHP1501 through in vitro tasks. Therefore, DHP1501 could be a candidate of functional food for alleviating hypertension.
Keywords
Eleutherococcus sessiliflorus fruits; Hypertension; Endothelial nitric oxide synthase; Angiotensin converting enzyme;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Zaluski, D., Olech, M., Verpoorte, R., Khan, I., Kuzniewski, R. and Nowak, R. (2017) Phytoconstituents and nutritional properties of the fruits of Eleutherococcus divaricatus and Eleutherococcus sessiliflorus: A study of non-European species cultivated in Poland. Oxid. Med. Cell. Longev. 2017: Article ID 8374295.
2 Jung, S. K. and Lee, H. J. (2010) Functional investigation of Ogaza extract. Food. Eng. Prog. 14: 183-187.
3 In, S. J., Lee, D. Y., Seo, K. H., Nam, T. G., Kim, D. O., Kim, G. S., Noh, H. J., Kim, G. W., Seo, W. D., Kang, H. C. and Baek, N. I. (2012) Anti-oxidant activity of phenolic compound isolated from the fruits of Acanthopanax sessiliflorus Seeman. J. Appl. Biol. Chem. 55: 217-220.   DOI
4 Lee, S., Lee, Y. S., Jung, S. H., Ji, J., Shin, K. H., Kim, B. K. and Kang, S. S. (2013) Antitumor and immunostimulating activities of Acanthopanax sessiliflorus fruits. Nat. Prod. Sci. 9: 112-116.
5 Jung, I. H., Kim, S. E., Lee, Y. G., Kim, D. H., Kim, H., Kim, G. S., Back, N. I. and Lee, D. Y. (2018) Antihypertensive effect of ethanolic extract from Acanthopanax sessiliflorus fruits and quality control of active compounds. Oxid. Med. Cell. Longev. 2018: Article ID 5158243.
6 Zhao, Y., Vanhoutte, P. M. and Leung, S. W. S. (2015) Vascular nitric oxide: Beyond eNOS. J. Pharmacol. Sci. 129: 83-94.   DOI
7 Benjamin, N. and Vane, J. (1996) Nitric oxide and hypertension. Circulation 94: 1197-1198.   DOI
8 Paul, M., Mehr, A. P. and Kreutz, R. (2006) Physiology of local renin-angiotensin systems. Physiol. Rev. 86: 747-803.   DOI
9 Abegaz, T. M., Shehab, A., Gebreyohannes, E. A., Bhagavathula, A. S. and Elnour, A. A. (2017) Nonadherence to antihypertensive drugs: A systematic review and meta-analysis. Medicine (Baltimore) 96: e5641.   DOI
10 Ong, K. L., Cheong, B., Man, Y. B., Lau, C. P. and Lam, K. (2006) Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 49: 69-75.
11 Kjeldsen, S. E. (2018) Hypertension and cardiovascular risk: General aspects. Pharmacol. Res. 129: 95-99.   DOI
12 Sun, Z. (2015) Aging, arterial stiffness, and hypertension. Hypertension 65: 252-256.   DOI
13 Poulter, N. R., Prabhakaran, D. and Caulfield, M. (2015) Hypertension. The Lancet 386: 22-28.   DOI
14 Carretero, O. A. and Oparil, S. (2000) Essential hypertension. Part I: Definition and etiology. Circulation 101: 329-335.   DOI
15 2016 국민건강통계. (2016) 보건복지부 질병관리본부. Available from: http://www.index.go.kr/potal/main/EachDtlPageDetail.do?idx_cd=1438
16 Jackson, R. E. and Bellamy, M. C. (2015) Antihypertensive drugs. BJA education 15: 280-285.   DOI
17 Joshi, V. D., Dahake, A. P. and Suth, A. P. (2010) Adverse effects associated with the use of antihypertensive drugs: An overview. Int. J. Pharmtech. Res. 2: 10-13.
18 Schoolwerth, A. C., Sica, D. A., Ballermann, B. J. and Wilcox, C. S. (2001) Renal considerations in angiotensin converting enzyme inhibitor therapy. Circulation 104: 1985-1991.   DOI
19 Boix, E., Zapater, P., Pico, A. and Moreno, O. (2005) Teratogenicity with angiotensin II receptor antagonists in pregnancy. J. Endocrinol. Invest. 28: 1029-1031.   DOI
20 Ryoo, H. S., Park, S. Y., Chang, S. Y. and Yook, C. S. (2003) Triterpene components from the leaves of Acanthopanax sessiliflorus Seem. Kor. J. Pharmacog. 34: 269-273.
21 Lee, S., Kim, B. K., Cho, S. H. and Shin, K. H. (2002) Phytochemical constituents from the fruits of Acanthopanax sessiliflorus. Arch. Pharm. Res. 25: 280-284.   DOI
22 [별표 1] "식품에 사용할 수 있는 원료"의 목록. (2018) 식품의약품안전처. 식품의 기준 및 규격 제2018-54호.
23 本草綱目 卷三十六 木之三 灌木類五十一種 五加 本經 上品集解. 한의학고전DB. Available from: https://mediclassics.kr/books/190/volume/43