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Quantification of Caffeoylquinic Acids and the Effect of the Cacalia hastata var. orientalis Extract on Acetylcholinesterase Activity and Peroxynitrite Concentration  

Nugroho, Agung (Department of Agro-Industrial Technology, Lambung Mangkurat University)
Choi, Jae Sue (Department of Food Nutrition, Pukyong University)
Park, Hee-Juhn (Department of Pharmaceutical Engineering, Sangji University)
Publication Information
Korean Journal of Pharmacognosy / v.48, no.3, 2017 , pp. 243-247 More about this Journal
Abstract
To find the anti-Alzheimer's activity of Cacalia hastata var. orientalis (Compositae), caffeoylquinic acids were analyzed in this plant by HPLC and the inhibitory activities of the extract on cholinesterases including acetylcholinesterase (AChE) and butyrylcholinesterse (BChE) and peroxynitrite ($ONOO^-$) were assayed. Sum of caffeoylquinic acids in the 80% MeOH extract was quantitatively higher in leaves (35.8% of the extract) than in stems (3.7%). The compound, 3,5-dicaffeoylquinic acid, was contained in the highest amount in the leaf (44.32 mg/g dry weight). The $IC_{50}s$ of the 80% MeOH extract were shown to be $67.45{\mu}g/ml$ for AChE, and $8.59{\mu}g/ml$ (for $ONOO^-$), respectively, suggesting that the leaves would have the anti-Alzheimer's activity due to the high content of caffeoylquinic acids.
Keywords
Cacalia hastata var. orientalis; Compositae; Caffeoylquinic acids; Acetylcholinesterase; Peroxynitrite; Anti-Alzheimer;
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