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Antifungal Effect of Sanguisorba officinalis L. fractions on Candida albicans  

Lee, Jae-Hyeok (Department of Oriental Pharmaceutical Development, Nambu University)
Choi, Bong-Sil (Department of Nursing, Nambu University)
Park, Jeong-Sook (Department of Nursing, Nambu University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.48, no.2, 2017 , pp. 166-171 More about this Journal
Abstract
We have studied the antifungal effect of 19 medicinal plants with paper disc diffusion method against candida albicans. As a result, Sanguisorba officinalis L., Cinnamomum cassia, Rheum coreanum, Perilla frutescens and Eugenia caryophyllata have been found to be effective against C. albicans. Among these, Sanguisorba officinalis L. was most effective at 24 hours and 48 hours. Its clear zone diameter was 17 mm for 24 hours and 16 mm for 48 hours. The antifungal activity of the solvent fraction of Sanguisorba officinalis L. by n-hexane, chloroform, ethyl acetate and n-butanol was the best for the chloroform fraction of 28 mm for 24 hours and 18 mm for 48 hours. The MIC concentration of the chloroform fraction was $80{\mu}g/50{\mu}l$ at 24 hours and $240{\mu}g/50{\mu}l$ at 48 hours.
Keywords
Sanguisorba officinalis L.; Candida albicans; Antifungal effect; Chloroform fraction;
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