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Longevity Property of Ethyl acetate Fraction of Dried Zingiber officinale in Caenorhabditis elegans  

Lee, Eun Byeol (College of Pharmacy, Woosuk University)
Kim, Jun Hyeong (College of Pharmacy, Woosuk University)
Leem, Jae-Yoon (College of Pharmacy, Woosuk University)
Kim, Hye-Soo (Hanpoong Pharm. Co., LTD.)
Kim, Dae-Sung (Hanpoong Pharm. Co., LTD.)
Kim, Ju Eun (College of Pharmacy, Woosuk University)
Kim, Hyo Sin (College of Pharmacy, Woosuk University)
Lee, Jeong Ho (Sunchang Research Institute of Health and Longevity)
Moon, Kwang Hyun (Sunchang Research Institute of Health and Longevity)
Jeong, Kyung Ok (Sunchang Research Institute of Health and Longevity)
Han, Sooncheon (College of Pharmacy, Woosuk University)
Kim, Dae Keun (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.48, no.1, 2017 , pp. 25-30 More about this Journal
Abstract
This study was performed to evaluate the lifespan extending effects of the dried ginger (Zingiber officnale Roscoe, Zingiberaceae). Ethanol extract of the dried ginger was successively partitioned as methylene chloride, ethyl acetate, n-butanol and $H_2O$ soluble fractions, and lifespan-extending effects of the fractions were investigated using Caenorhabditis elegans model system. Ethyl acetate-soluble fraction showed the most potent longevity property. Furthermore, ethyl acetate-soluble fraction elevated thermal stress tolerance, and increased expression of stress resistance protein. Further studies were performed to investigate several aging-related factors such as reproduction, food intake, growth and movement of C. elegans. The results revealed that there were no significant changes in aging-related factors including reproduction, food intake and growth, however, ethyl acetate-soluble fraction treatment led to an up-regulation of locomotory ability of aged worms, suggesting ethyl acetate-soluble fraction affected healthspan as well as lifespan of nematode.
Keywords
Zingiber officinale; Caenorhabditis elegans; Longevity;
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