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Screening of 50 Korean Herbal formulas with Inhibitory Effects on Acetylcholinesterase Activity and Amyloid-β Aggregation  

Lim, Hye-Sun (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Kim, Yoonju (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Kim, Ohn Soon (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Jeong, Soo-Jin (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.47, no.3, 2016 , pp. 287-294 More about this Journal
Abstract
Acetylcholinesterase (AChE) activation and amyloid-${\beta}$ ($A{\beta}$) aggregation are major biological markers of Alzheimer's disease. In the present study, we evaluated the inhibitory effects of 50 kinds of herbal formulas on AChE activity and $A{\beta}$ aggregation. Among them, Hwanglyeonhaedok-tang, Cheonwangbosim-dan, Makmundong-tang, and Gamisoyo-san had a potent effects on the inhbition of AChE activity. Sosiho-tang, Samsoeum, Cheonsimyeunjaeum, and Bunsimgieum exerted to have the inhibitory activity on $A{\beta}$ aggregation. In addition, these 8 herbal formulas showed the 3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity, indicating their antioxidant activities.
Keywords
Dementia; Acetylcholinesterase; Amyloid-${\beta}$; Antioxidant; Herbal formula;
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Times Cited By KSCI : 8  (Citation Analysis)
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