Decursin from Angelica gigas Nakai Promotes Cytotoxicity and Induces Apoptosis in THP-1 cells, a Human Acute Monocytic Leukemia
![]() |
Kim, Nam-Seok
(Department of Food & Biotechnology, Woosuk University)
Jeong, Seung-Il (Jeonju Agrobio-Materials Institute (JAMI)) Kim, Jong-Seok (Department of Rehabilitation studies, Woosuk university) Oh, Mi-Jin (Korea Food Research Institute) Oh, Chan-Ho (Department of Food & Biotechnology, Woosuk University) |
1 | Kang, S. Y., Lee, K. Y., Park, M. J., Kim, Y. C., Markelonis, G. J., Oh, T. H. and Kim, Y. C. (2003) Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice. Neurobiol. Learn. Mem. 79: 11-18. DOI |
2 | Kim, J. H., Jeong, J. H., Jeon, S. T., Kim, H., Ock, J., Suk, K., Kim, S. I., Song, K. S. and Lee, W. H. (2006) Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages. Mol. Pharmacol. 69: 1783-1790. DOI |
3 | Son, S. H., Park, K. K., Park, S. K., Kim, Y. C., Kim, Y. S., Lee, S. K. and Chung, W. Y. (2011) Decursin and decursinol from Angelica gigas inhibit the lung metastasis of murine colon carcinoma. Phytother Res. 25: 959-964. DOI |
4 | Yim, D., Singh, R. P., Agarwal, C., Lee, S. and Chi, H. and Agarwal, R. (2005) A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 1; 65: 1035-1044. |
5 | Kim, J. H., Jeong, S. J., Kwon, H. Y., Park, S. Y., Lee, H. J., Lee, H. J., Lieske, J. C. and Kim, S. H. (2010) Decursin prevents cisplatin-induced apoptosis via the enhancement of antioxidant enzymes in human renal epithelial cells. Biol. Pharm. Bull. 33: 1279-1284. DOI |
6 |
Li, L., Li, W., Jung, S. W., Lee, Y. W. and Kim, Y. H. (2011) Protective effects of decursin and decursinol angelate against amyloid |
7 | Park, K. W., Choi, S. R., Shon, M. Y., Jeong, I. Y., Kang, K. S., Lee, S. T., Shim, K. H. and Seo, K. I. (2007) Cytotoxic effects of decursin from Angelica gigas Nakai in human cancer cells. J. Korea Soc. Food Sci. Nutr. 36: 1385-1390. DOI |
8 | Lee, K. Y., Sung, S. H. and Kim, Y. C. (2008) Cognitiveenhancing activity of decursin derivatives. Kor. J. pharmacogn. 39: 86-90. |
9 | Bae, E. A., Han, M. J., Kim, N. J. and Kim, D. H. (1998) Anti-Helicobacter pylory activity of herbal medicines. Biol. Pharm. Bull. 21: 990-992. DOI |
10 | Lee, S., Shin, D. S., Kim, J. S., Oh, K. B. and Kang, S. S. (2003) Antibacterial coumarins from Angelica gigas roots. Arch. Pharm. Res. 26: 449-452. DOI |
11 | Lee, Y. Y., Lee, S., Jin, J. L. and Yun-Choi, H. S. (2003) Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Arch. Pharm. Res. 26: 723-726. DOI |
12 | Lee, S. H., Lee, Y. S., Jung, S. H., Shin, K. H., Kim, B. K. and Kang, S. S. (2003) Antioxidant activities of decursinol angelate and decursin from angelica gigas roots. Nat. Prod. Sci. 9: 170-173. |
13 | Kim, H. H., Ahn, K. S., Han, H., Choung, S. Y., Choi, S. Y. and Kim, I. H. (2005) Decursin and PDBu: Two PKC activators distinctively acting in the megakaryocytic differentiation of K562 human erythroleukemia cells. Leuk. Res. 29: 1407-1413. DOI |
14 | Park, K. W., Choi, S. R., Shon, M. Y., Jeong, I. Y., Kang, K. S., Lee, S. T., Shim, K. H. and Seo, K. I. (2007) Cytotoxic effects of decursin from Angelica gigas Nakai in human cancer cells. J. Korean Soc. Food Sci. Nutr. 36: 1385-1390. DOI |
15 | Kim, B. S., Seo, H., Kim, H. J., Bae, S. M., Son, H. N., Lee, Y. J., Ryu, S., Park, R. W. and Nam, J. O. (2015) Decursin from Angelica gigas Nakai inhibits B16F10 melanoma growth through induction of apoptosis. J. Med. Food 18b 1121-1127. |
16 |
Li, L., Du, J., Zou, L., Xia, H., Wu, T., Kim, Y. and Lee, Y. (2015) The neuroprotective effects of decursin isolated from Angelica gigas Nakai against amyloid |
17 | Birch, D. E., Kolmodin, L., Laird, W. J., McKinney, N., Wong, J., Young, K. K. Y., Zangenberg, G. A. and Zoccoli, M. A.(1996) Simplified Hot-Start PCR, Nature 381: 445-446. DOI |
18 | Kim, H. H., Bang, S. S., Choi, J. S., Han, H. and Kim, I. H. (2005) Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells. Cancer Lett. 223: 191-201. DOI |
19 | Ahn, Q., Jeong, S. J., Lee, H. J., Kwon, H. Y., Han, I., Kim, H. S., Lee, H. J., Lee, E. O., Ahn, K. S., Jung, M. H., Zhu, S., Chen, C. Y. and Kim, S. H. (2010) Inhibition of cyclooxygenase- 2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells. Cancer Lett. 298: 212-221. DOI |
20 | Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxic assays. J. Immunol. Methods 65: 55-63. DOI |
21 | Dowdy, S., Weardon, S. and Chilko, D. (2004) Statistics for research (3rd ed). Wiley-interscience, USA 285-287. |
22 | Park, K. W., Choi, S. R., Hong, H. R., Kim, J. Y., Shon, M. Y. and Seo, K. I. (2007) Biological activities of methanol extract of Angelica gigas Nakai. Korean J. Food Preserv. 14: 655-661. |
23 | Haupt, S., Berger, M., Goldberg, Z. and Haupt, Y. (2003) Apoptosis- the p53 network. J. Cell Sci. 116: 4077-4085. DOI |
24 | Dy, G. K. and Adjei, A. A. (2002) Novel targets for lung cancer therapy: part I. J. Clin. Oncol. 20: 2881-2294. DOI |
25 | Son, C. Y., Baek, I. H., Song, G. Y., Kang, J. S. and Kwon, K. I. (2009) Pharmacological effect of decursin and decursinol angelate from Angelica gigas Nakai. Yakhak Hoeji 53: 303-313. |
26 | Kim, J. H., Kim, D. H., You, J. H., Kim, C. H., Kwon, M. C., Seong N. S., Lee, S. E. and Lee H. Y.(2005) Immuno-regulatory activ?ties of various fractions from Ehpedrae sinica Stapf, Rubus Coreanus Miq. and Angelica gigas nakai extracts with untrasonification. Korean J. Medicinal Crop. Sci. 13: 161-170. |
27 | Lee, S., Lee, Y. S., Jung, S. H., Shin, K. H., Kim, B. K. and Kang, S. S. (2000) Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch. Pharm. Res. 26: 727-730. |
28 | 국립암센터 (2014) Annual report of cancer statistics in Korea in 2012. National Cancer center 1-179. |
29 | Cho, Y. J. and Hou, W. N. (2005) Effects of dietary bong-ip (Morus alba L.), gam-chei (Glycyrrhiza glabra), sol-ip (Pinus densiflora) and dang-gi (Angelica gigas) on serum composition in rats. Korean J. Food culture 20: 123-129. |
30 | Han, E. J., Roh, S. B. and Bae, S. J. (2000) Effects of quinone reductase induction and cytoxicity of the Angelica radix extracts. J. Korean Soc. Food Sci. Nutr. 29: 147-152. |
31 | Wessler, S., Kleiger, R. E., Cornfield, J. and Teitelbaum, S. L. (1974) Coumarin theraphy in acute myocardial infarction. A hobson's choice. Arch. Intem. Med. 134: 774-779. DOI |
32 | Ristola, P. and Pyorala, K. (1972) Determinants of the response to coumarin anticoagulants in patients with acute myocardial infarction. Ata. Med. Scand. 192: 183-188. |
33 | Kang, S. Y., Lee, K. Y., Sung, S. H., Park, M. J. and Kim, Y. C. (2001) Coumarins isolated from Angelica gigas inhibit acetylcholine esterase: structure-activity relationships. J. Nat. Prod. 64: 683-685. DOI |
![]() |