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Inhibition of MMP-1 Expression and Collagen Synthesis Activity of Ultrasonication Processed Ginseng Flower Buds Extract  

Kim, Shin Jung (Ginseng Research Center, Koyeon)
Nam, Yun Min (Ginseng Research Center, Koyeon)
Kim, Yong Min (The Department of Oriental Medical and Herbal Cosmetic Sciences, Semyung University)
Ko, Sung Kwon (Ginseng Research Center, Koyeon)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.2, 2015 , pp. 154-159 More about this Journal
Abstract
This study was to evaluate the effect of isopropyl alcohol fraction of ultrasonication processed ginseng flower buds(GFB-IF) on the collagen synthesis activity and inhibition of MMP-1 suppression in UV-irradiated human dermal fibroblasts. The higher contents of ginsenoside Rg2(8.234%), Rh1(5.749%), F4(3.881%) in isopropyl alcohol fraction of ginseng flower buds obtained by ultrasonication process at 600W(100℃) for 16 hours. GFB-IF had collagen synthesis effect. GFB-IF induced a significant dose-dependent decrease in the expression for MMP-1 protein. These results suggest that GFB-IF is a potential candidate for the prevention and treatment of wrinkle improving.
Keywords
Collagen; F4; Ginseng flower buds; Ginsenoside Rg2; MMP-1; Rh1;
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