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Antioxidant Activities and Anti-inflammatory Effects of Rice Bran and Wheat Bran Extracts  

Moon, Jungsun (Department of Pharmacy, College of Pharmacy, SahmYook University)
Choi, Sungsook (Department of Pharmacy, College of Pharmacy, SahmYook University)
Lee, Sookyeon (Korea Re-Creation Institute of Phytochemicals, College of Pharmacy, SahmYook University)
Yim, Dongsool (Department of Pharmacy, College of Pharmacy, SahmYook University)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.2, 2015 , pp. 140-147 More about this Journal
Abstract
The antioxidative activities and anti-inflammatory effects of rice bran and wheat bran were investigated. To determine the antioxidant activity, total phenolic content. DPPH reaction, ABTS reaction and FRAP assay were tested. To investigate the anti-inflammatory effect, the inhibition of NO production, IL-6 production and TNF-${\alpha}$ production were observed. The total phenolic contents were 46.4 mg/g in the BuOH fraction of rice bran (RBB) and 69.0 mg/g in BuOH fraction of wheat bran (WBB). EtOAc fraction of rice bran (RBE), EtOAc fraction of wheat bran (WBE), RBB and WBB showed high radical scavenging activity at a concentration of 5 mg/ml. Scavenging activity of DPPH radical were 89.04% in RBB and 91.53% in WBE. Scavenging activity of ABTS radical were 88.53% in RBB and 90.39% in WBB. In case of FRAP assay, RBE reduced 0.805 mM/mg of Fe2+ and WBE reduced 1.521 mM/mg of Fe2+. RBB, RBE, WBB and WBE showed concentration dependent inhibition of LPS induced NO production (RBE: 57.38%, WBE: 76.85%), IL-6 production (RBE: 92.08%, WBB: 92.57%), TNF-α production (RBE: 86.33%, WBE: 85.05%) at a concentration of 100 μg/ml of each fraction. These results showed that RBB, RBE, WBB and WBE have strong antioxidative activities and anti-inflammatory effects and show the possibilities of a new natural antioxidants and anti-inflammatory medicines.
Keywords
Rice bran; Wheat bran; Antioxidant activity; Anti-inflammatory;
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Times Cited By KSCI : 9  (Citation Analysis)
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