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Anti-inflammatory Effects of $1{\beta}$,$6{\alpha}$-Dihydroxyeudesm-4(15)-ene Isolated from Myrrh on LPS-induced Neuroinflammation in BV2 cells  

Kim, Dong-Cheol (College of Pharmacy, Wonkwang University)
Yoon, Chi-Su (College of Pharmacy, Wonkwang University)
Ko, Wonmin (College of Pharmacy, Wonkwang University)
Lee, Dong-Sung (Inha Research Institute for Medical Sciences, Inha University School of Medicine)
Kim, Dae-Sung (Hanpoong Pharm & Foods Co., Ltd.)
Cho, Hyoung-Kwon (Hanpoong Pharm & Foods Co., Ltd.)
Seo, Jungwon (College of Pharmacy, Wonkwang University)
Kim, Sung Yeon (College of Pharmacy, Wonkwang University)
Oh, Hyuncheol (College of Pharmacy, Wonkwang University)
Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.1, 2015 , pp. 12-16 More about this Journal
Abstract
Myrrh is a resinous substance obtained from Commiphora trees, which has long been used as an antiseptic agent. A sesquiterpene, $1{\beta}$, $6{\alpha}$-dihydroxyeudesm-4(15)-ene (DE), was isolated from the hot water extract of Myrrh. In the present study, we found that DE attenuates the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells. DE significantly inhibited LPS-induced production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) in BV2 microglia in a concentration-dependent manner without cytotoxic effect. Furthermore, DE dose-dependently suppressed the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results suggest that DE may be a good candidate to regulate LPS-induced inflammatory response.
Keywords
Myrrh; $1{\beta}$, $6{\alpha}$-Dihydroxyeudesm-4(15)-ene; Anti-neuroinflammation; BV2 cells;
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