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Effect of Cell-Wall Broken Spores of Ganoderma lucidum(Leyss. ex.Fr.) Karst on the Lipid Accumulation and Body Weight Reduction in C57BL/6J Mice fed High-Fat Diet  

Pak, Kum-Ju (The Food and Culture Institute, Pulmuone Co., Ltd.)
Kang, Jung Il (The Food and Culture Institute, Pulmuone Co., Ltd.)
Kim, Tae-Seok (The Food and Culture Institute, Pulmuone Co., Ltd.)
Lee, Sang-Yun (The Food and Culture Institute, Pulmuone Co., Ltd.)
Yeo, Ik-Hyun (The Food and Culture Institute, Pulmuone Co., Ltd.)
Publication Information
Korean Journal of Pharmacognosy / v.45, no.4, 2014 , pp. 346-353 More about this Journal
Abstract
This study was performed to investigate the effects of cell-wall broken spores of Ganoderma lucidum on the lipid accumulation and body weight reduction in C57BL/6J mice. Six-week-old C57BL/6J mice were randomly divided into 5 groups and assigned to one of these groups; normal chew diet(Nor) group, high-fat diet(HFD) group, HFD plus spores of Ganoderma lucidum 800 mg/kg/day (HFD + GS/B) group, HFD plus cell-wall broken spores of Ganoderma lucidum 400 mg/kg/day (HFD + BGS/A) group and finally HFD plus cell-wall broken spores of Ganoderma lucidum 800mg/kg/day (HFD + BGS/B). The experimental groups which were treated oral co-administration with cell-wall broken(or original) spores of Ganoderma lucidum and HFD significantly attenuated accumulative body weight gain, compared with HFD group. Administration of these experimental materials also resulted in significant reduction not only the serum levels of total cholesterol, homocysteine but also the lipid accumulation in liver tissue. But in the almost of results the cell-wall broken spores of Ganoderma lucidum were evaluated superior than the original one. These results indicate that cell-wall broken spores of Ganoderma lucidum may inhibit the lipid accumulation in blood as well as liver tissue. Therefore it may be a valuable candidate for the therapy preventing obese induced hyperlipidemic symptoms.
Keywords
Cell-wall broken spores of Ganoderma lucidum; High-fat diet; Lipid accumulation; Homocysteine; Weight gain reduction;
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