Browse > Article

Ameliorative Effect of Yacon Containing Herbal Mixture against Benign Prostatic Hyperplasia Symptoms  

Park, Jeong Sook (College of Pharmacy, Chungbuk National University)
Lee, Tae Woong (College of Pharmacy, Chungbuk National University)
Park, Bong Soo (College of Pharmacy, Chungbuk National University)
Han, Sang-Bae (College of Pharmacy, Chungbuk National University)
Hong, Jin Tae (College of Pharmacy, Chungbuk National University)
Han, Kun (College of Pharmacy, Chungbuk National University)
Publication Information
Korean Journal of Pharmacognosy / v.45, no.3, 2014 , pp. 233-239 More about this Journal
Abstract
We evaluated the benign prostatic hyperplasia (BPH) with Yacon pill, the preparation composed of Smallanthus sonchifolius, Torilis japonica and Acorus gramineus. A total of 45 rats were divided into five groups. One group was used as a control and the other groups received subcutaneous injections of testosterone for 4 weeks to induce BPH. Yacon pill extract (200 or 400 mg/kg) was administered daily for 4 weeks to two groups by oral gavage concurrently with testosterone. The rats euthanized, the prostate and body weights were recorded, and tissues were subjected to hormone assay. In addition, we investigated proliferating cell nuclear antigen (PCNA) expression in the prostate using immunoblotting. Rats with BPH showed significantly increased prostate weights, increased dihydrotestosterone (DHT) levels in the serum and increased PCNA expression in the prostate; however, Yacon pill extracts treated rats showed significant reduction of prostate weights, DHT levels and PCNA expression compared with the BPH group. Conclusively, Yacon pill showed the possibility as ameliorable agents of BPH symptoms.
Keywords
BPH; Yacon; Testosterone; $5{\alpha}$-Reductase; DHT;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Wu, J. P. and He, L. Y.(2007) RP-HPLC determination of content of $\alpha$-asarone and related substances. J. Pharma. Anal. 3: 364-366.
2 Mythili, A. M. N., Immanuel, S. C., Rajasekharan, P. E., Rajasekharan, C., Tharachand, C., Rao, V. K. and Munirajappa, H. (2013) HPLC profiling of $\beta$-asarone content and cytogenetic studies of medicinally important Indian Acorus calamus l. Int. J. pharm. Sci. 22: 73-78.
3 Shin, I. S., Lee, M. Y., Ha, H. K., Seo, C. S. and Shin, H. K. (2012) Inhibitory effect of Yukmijihwang-tang, a traditional herbal formula against testosterone-induced benign prostatic hyperplagia in rats. BMC Complement. & Altern. Med. 12: 48-54.   DOI
4 Koutsari, C., Ali, A. H., Nair, K. S., Rizza, R. A., O'Brien. P., Khosla, S. and Jensen, M. D. (2009) Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women. J. Clin. Endocrinol. Metab. 94: 3414-3423.   DOI
5 Aybar, M. J., Snchez Riera A. N., Grau, A. and Snchez, S. S. (2001) Hypoglycemic effect of the water extract of Smallanthus sonchifolius (yacon) leaves in normal and diabetic rats. J. Ethnopharm. 74: 125-132.   DOI   ScienceOn
6 Habib, N. C., Honor, S. M., Genta, S. B. and Snchez, S. S. (2011) Hypolipidemic effect of Smallanthus sonchifolius (yacon) roots on diabetic rats. biochemical approach. Chem. Biol. Interact. 194: 31-39.   DOI   ScienceOn
7 Yan, X., Suzuki, M., Ohnishi-Kameyama, M., Sada, Y., Nakanishi, T. and Nagata, T. (1999) Extraction and identification of antioxidants in roots of yacon (Smallanthus sonchifolius). J. Agric. Food Chem. 47: 4711-4713.   DOI   ScienceOn
8 Simonovska, B., Vovk, I., Andrenek, S., Valentov, K. and Ulrichov, J. (2003) Investigation of phenolic acids in yacon (Smallanthus sonchifolius) leaves and tubers. J. Chromatography A, 1016: 89-98.   DOI   ScienceOn
9 Goto, K., Fukai, K., Hikida, J., Nanjo, F. and Hara, Y. (1995) Isolation and structural analysis of oligosaccharides from yacon (Polymnia sonchifolia). Biosci. Biotechnol. Biochem. 59: 2346-2347.   DOI
10 Park. J. S., Hwang, S. Y. and Han, K. (2009) The spermatogenic effect of 50% ethanol extracts of Yacon in healthy volunteers. Yakhak Haeji, 53: 250-258.
11 Hiipakka, R. A., Zhang, H. Z., Dai, W., Dai, Q. and Liao, S. (2002) Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols. Biochem. Pharmacol. 63: 1165-1176.   DOI   ScienceOn
12 Sun, J., Xiang, H., Yang, L. L. and Chen, J. B. (2011) A review on steroidal 5$\alpha$-reductase inhibitors for treatment of benign prostatic hyperplasia. Curr. Med. Chem. 18: 3576-3589.   DOI   ScienceOn
13 Park, W. S., Son, E. D., Nam, G. W., Kim, S. H., Noh, M. S., Lee, B. G., Jang, I. S., Kim, S. E., Lee, J. J. and Lee, C. H. (2003) Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase. Planta Med. 69: 459-461.   DOI   ScienceOn
14 Traish, A, M., Hassani, J., Guay, A. T., Zitzmann, M. and Hansen, M. L. (2011) Adverse side effects of 5$\alpha$-reductase inhibitors therapy: Persistent diminished libido and erectile dysfunction and depression in a subset of patients. J. Sexual Medicine, 8: 872-884.   DOI   ScienceOn
15 Pumthong, G., Asawanonda, P., Varothai, S., Jariyasethavong, V., Triwongwaranat, D., Suthipinittharm, P., Ingkaninan, K., Leelapornpisit, P. and Waranuch, N. (2012) Curcuma aeruginosa, a novel botanically derived 5$\alpha$-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study. J. Dermatolog. Treat. 23: 385-392.   DOI
16 Bach, D., Schmitt, M. and Ebeling, L. (1997) Phytopharmaceutical and synthetic agents in the treatment of benign prostatic hyperplasia (BPH). Phytomedicine 3: 309-313.   DOI
17 Chen, Q. X., Miao, J. K., Li, C., Li, X. W., Wu, X. M. and Zhang, X. P. (2013) Anticonvulsant activity of acute and chronic treatment with a-asarone from Acorus gramineus in seizure models. Biol. Pharm. Bull. 36: 23-30.
18 Hwang, E. I., Lee, S. K., So, S. H., Koo, B. S., Han, G. and Kim, N. M. (2007) Isolation and development of quantitative determination of Torilin from the Torilis Fructus. Kor. J. Pharmacogn. 38: 321-326.
19 Yang, H., Yuan, B., Chen, H. and Li, F. (2004) HPLC determination and pharmacokinetics of chlorogenic acid in rabbit plasma after an oral dose of Flos Lonicerae extract. J. Chromatogr. Sci. 42: 173-176.   DOI
20 Wen, J., Kang, L., Liu, H., Xiao, Y., Zhang, X. and Chen, Y. (2012) A validated UV-HPLC method for determination of chlorogenic acid in Lepidogrammitis drymoglossoides (Baker) Ching, Polypodiaceae. Pharmacognosy Res. 4: 148-153.   DOI
21 Ma, W. C., Zhang, Q., Li, H., Larregieu, C. A., Zhang, N., Chu, T., Jin, H. and Mao, S. J. (2013) Development of intravenous lipid emulsion of $\alpha$-asarone with significantly improved safety and enhanced efficacy. Int. J. Pharm. 42: 21-30.