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Effect of Steamed Codonopsis lanceolata on Spatial Learning and Memory in Mice  

Weon, Jin Bae (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Yun, Bo-Ra (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Lee, Jiwoo (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Eom, Min Rye (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Ko, Hyun-Jeong (Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University)
Lee, Hyeon Yong (Department of Teaics, Seowon University)
Park, Dong-Sik (Functional food & Nutrition Division, Department of Agrofood Resources)
Chung, Hee-Chul (Newtree CO., LTD.)
Chung, Jae Youn (Newtree CO., LTD.)
Ma, Choong Je (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Publication Information
Korean Journal of Pharmacognosy / v.45, no.1, 2014 , pp. 48-54 More about this Journal
Abstract
Alzheimer's disease is progressive neurodegenerative disorder by the loss of memory and learning abilities. Codonopsis lanceolata (C. lanceolata) is traditional medicinal plant used for the treatment of inflammatory diseases. The aim of study was to evaluate the effect of steamed C. lanceolata on scopolamine-induced memory impairment in the Morris water maze test and passive avoidance test. In addition, this study investigated the neuroprotective effects of steamed C. lanceolata on glutamate-induced cell death in HT22 cells using MTT assay. The results showed that steamed C. lanceolata (500 mg/kg body weight, p.o.) reversed spatial memory impairment by scopolamine in Morris water maze test and passive avoidance test. Steamed C. lanceolata attenuated memory impairment by scopolamine compared with common C. lanceolata. In addition, administration of steamed C. lanceolata significantly also reduced cell death. We suggest that steaming process more improve cognitive enhancing and neuroprotective effect of C. lanceolata than common C. lanceolata.
Keywords
Codonopsis lanceolata; Cognitive enhancing effect; Neuroprotective effect; Steaming process;
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Times Cited By KSCI : 6  (Citation Analysis)
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