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The Anti-inflammatory Effects of Malva verticillata L. Oil Induced by Lipopolysaccharide with RAW 264.7 cells  

Oh, Seong-Hwa (R&D Center, NewMedion Corporation)
Choi, Soo-Yeon (R&D Center, NewMedion Corporation)
Lee, Sang-Hwa (Department of Food Service Industry, and Bio Organic Material and Food Center, Seowon University)
Kim, Dong-Seok (Department of Food Service Industry, Seowon University)
Park, Sung-Min (R&D Center, NewMedion Corporation)
Publication Information
Korean Journal of Pharmacognosy / v.45, no.1, 2014 , pp. 23-27 More about this Journal
Abstract
Atopic dermatitis (AD) were caused by localized hypersensitivity reaction to an allergen. Therefore, to reduce inflammatory response of AD had been developed that natural extracts and oils with anti-inflammatory activities. This study were investigated that anti-inflammatory effects of Malva verticillata L. oil induced by LPS with RAW 264.7 cells. We measured to production of NO and expression of COX-2, iNOS, TNF-${\alpha}$ by RT-PCR. The Malva verticillata L. oil had decreased the production of NO (p<0.05) and the mRNA level of iNOS in concentration dose dependent manner. In conclusion, this study have shown here may be of help to understand the action mechanism of the anti-inflammatory and we hope that Malva verticillata L. oil used in skin diseases such as AD.
Keywords
Malva verticillata L.; Natural oil; Anti-inflammatory; iNOS; Nitric Oxide;
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1 Lim, H. S., Kim, J. H., Ha, H. K., Seo, C. S. and Shin, H. K. (2012) Comparative Study of the Anti-inflammatory Effects of Menthae Herba from Korea and China. Kor J Pharmacogn. 43: 231-238.
2 Shimizu, N., Asahara, H., Tomoda, M., Gonda, R. and Ohara. N. (1991) Constituents of seed of Malva verticillata. VII. Structural features and reticuloendothelial system-potentiating activity of MVS-I, the major neutral polysaccharide. Chem. Pharm. Bull. 39: 2630-2632.   DOI   ScienceOn
3 A.O.C.S. Cd 3a-63. (1988) Official Methods and Recommended Practicies of the American Oil Chemists' Society, 3rd Edition.
4 Kim, W. S. and Lee, S. J. (2000) Studies on the Electrochemical Properties for Rancidity of Linoleic Acid. Korean J. Food and Nutr. 13: 306-364.
5 Umezu, T. (2012) Evaluation of the effects of plant-derived essential oils on central nervous system function using discrete shuttle-type conditioned avoidance response in mice. Phytother. Res. 26: 884-891.   DOI   ScienceOn
6 Warnke, P. H. and Becker, S. T. (2009) The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J. Craniomaxillofac. Surg. 37: 392-397.   DOI   ScienceOn
7 Jaenson, T. G. and Garboui, S. (2006) Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field. J. Med. Entomol. 43: 731-736.   DOI   ScienceOn
8 Minaiyan, M. and Ghannadi, A. R. (2011) Effects of extract and essential oil of Rosmarinus officinalis L. on TNBSinduced colitis in rats. Res. Pharm. Sci. 6: 13-21.
9 Szabo, M. A. and Varga, G. Z. (2011) Inhibition of quorumsensing signals by essential oils. Phytother. Res. 24: 782-786.
10 Choi. J. W., Seong. N. S. and Lee. Y. J.(2006) Effects of Malvae Semen and Abutili Semen on Anti-oxidation Activities. The Korea Journal of Herbology 21: 159-170.
11 Seo. B. I. (2012) A philological study on poisoning and side effects of Malvae Semen. The Journal of Heahgan Oriental Medical Acidemy 10: 33-35.
12 Tomoda, M., Asahara, H., Gonda, R. and Takada, K. (1992) Constituents of the seed of Malva verticillata. VIII. Smith degradation of MVS-VI, the major acidic polysaccharide, and anti-complementary activity of products. Chem. Pharm. Bull. 40: 2219-2221.   DOI   ScienceOn
13 Song, C. and Zhang, Y. (2013) Acute and subacute IL-1beta administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration. J. Neuroinflammation 10: 59.   DOI   ScienceOn
14 Han, S. and Lee, J. H. (2013) Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPSinduced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-kappaB activation. Immunopharmacol. Immunotoxicol. 35: 34-42.   DOI   ScienceOn
15 Neuman, M. G. and Nanau, R. M. (2011) In vitro anti-inflammatory effects of hyaluronic acid in ethanol-induced damage in skin cells. J. Pharm. Pharm. Sci. 14: 425-437.
16 Shao, D. Z. and Lin, M. (2008) Platonin inhibits LPS-induced NF-kappaB by preventing activation of Akt and IKKbeta in human PBMC. Inflamm. Res. 57: 601-606.   DOI
17 Tsai, M. L. and Lin, C. C. (2011) Antimicrobial, antioxidant, and anti-inflammatory activities of essential oils from five selected herbs. Biosci Biotechnol. Biochem. 75: 1977-1983.   DOI   ScienceOn
18 Yoon, W. J. and Kim, S. S. (2009) Abies koreana essential oil inhibits drug-resistant skin pathogen growth and LPS- induced inflammatory effects of murine macrophage. Lipids 44: 471-476.   DOI
19 Yoon, W. J. and Kim, S. S. (2009) Cryptomeria japonica essential oil inhibits the growth of drug-resistant skin pathogens and LPS-induced nitric oxide and pro-inflammatory cytokine production. Pol. J. Microbiol. 58: 61-68.
20 Lee, D. H., Sohn, D. S., Cho, D. Y., Kim, Y. Y. and Kim, Y. H. (2010) Anti-inflammatory and Anti-oxidant Effects of Sophora flavescens Root Extraction in Lipopolysaccharideactivated Raw 264.7 Cells. Kor. J. Med. Mycol. 15: 39-50.
21 Kwak, J. H. and Kim, I. H. (1974) Studies on the Anti-inflammatory Activity of Caragana chamlagu Roots. Kor. J. Pharmacogn. 5: 179-184.
22 Hunziker, T. (1997) Atopic dermatitis. Schweiz Med Wochenschr. 127: 390-394.
23 Hanifin, J. M. and Chan, S. (1988) Biochemical and immunologic mechanisms in atopic dermatitis: new targets for emerging therapies. J. Am. Acad. Dermatol. 41: 72-77.
24 Ha, J. S., Jung, H. J., Byun, H. J., Yoon, C. S., Kim, Y. H., Oh, I. B., Lee, J. H. and Ha, K. C. (2011) Evaluation of Atopy and Its Possible Association with Indoor Bioaerosol Concentrations and Other Factors at the Residence of Children. J. Environ Health Sci. 37: 406-417.
25 Ponvert, C. (2012) Allergic and non-allergic hypersensitivity to non-opioid analgesics, antipyretics and nonsteroidal antiinflammatory drugs in children: epidemiology, clinical aspects, pathophysiology, diagnosis and prevention. Arch. Pediatr. 19: 556-560.   DOI   ScienceOn