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Quantitative Analysis of Aucklandia Lappa Using Costunolide and Dehydrocostuslactone  

Eom, Min Rye (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Weon, Jin Bae (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Yun, Bo-Ra (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Lee, Jiwoo (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Ma, Choong Je (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.3, 2013 , pp. 235-241 More about this Journal
Abstract
Aucklandia lappa Decne (Compositae) has been used for treatment of abdominal pain, vomiting, diarrhea, chronic inflammation, and antibacterial effect. The quality of these herbs has been affected by many factors such as collection time, place, temperature, cultivation environment and manufacturing process. We used costunolide and dehydrocostuslactone as marker compounds for quality evaluation of rhizome of Aucklandia lappa. 66 samples of Aucklandia lappa were collected from those habitats in Korea and China. The developed HPLC-DAD method was applied to investigate for quality control of Aucklandia lappa samples. The average contents of the costunolide and dehydrocostuslactone were 2.3895% and 0.9258%, respectively. The principal component analysis (PCA) exhibited that classification of Aucklandia lappa according to origin not separated. Results of this study may be satisfactory applied to determination of content criteria of Aucklandia lappa.
Keywords
Aucklandia lappa; compositae; rhizome; costunolide; dehydrocostuslactone; HPLC; principal component analysis; content criteria;
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Times Cited By KSCI : 3  (Citation Analysis)
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