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DPPH Free Radical Scavengers from the Aerial Part of Trigonotis peduncularis Bentham  

Lee, Eun Byeol (College of Pharmacy, Woosuk University)
Ahn, Dalrae (College of Pharmacy, Woosuk University)
Lee, Tae Gwan (College of Pharmacy, Woosuk University)
Eun, Jae Soon (College of Pharmacy, Woosuk University)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Cha, Dong Seok (College of Pharmacy, Woosuk University)
Cui, Xun (College of Pharmacy, Woosuk University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Cho, Chong Hyeon (Jeollabuk-do Agricultural Research and Extension Servieces)
Kim, Dae Keun (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.3, 2013 , pp. 230-234 More about this Journal
Abstract
In the course of screening for antioxidant compounds by measuring the DPPH radical scavenging activity, a total extract of the aerial part of Trigonotis peduncularis (Boraginaceae) was found to show potent DPPH radical scavenging activity. Subsequent activity-guided fractionation of the methanolic extract of T. peduncularis led to the isolation of seven compounds, kaempferol (1), quercetin (2), trigonotin A (3), astragalin (4), trigonotin C (5), kaempferol-3-O-${\alpha}$-L-rhamnopyranosyl(1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (6), and rutin (7) from the active ethyl acetate soluble fraction. Their structures were elucidated by spectroscopic studies. Among seven compounds, compounds 1, 2, 4, 6 and 7 were isolated for the first time from this plant, and compounds 2 and 7 showed the significant DPPH free radical scavenging activities.
Keywords
Trigonotis peduncularis; Boraginaceae; DPPH radical;
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