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Tyrosinase Inhibitory Phenolic Constituents of Smilax china Leaves  

Kim, Sang Hyun (College of Pharmacy, Chungbuk National University)
Ahn, Jong Hoon (College of Pharmacy, Chungbuk National University)
Jeong, Ji Yeon (College of Pharmacy, Chungbuk National University)
Kim, Seon Beom (College of Pharmacy, Chungbuk National University)
Jo, Yang Hee (College of Pharmacy, Chungbuk National University)
Hwang, Bang Yeon (College of Pharmacy, Chungbuk National University)
Lee, Mi Kyeong (College of Pharmacy, Chungbuk National University)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.3, 2013 , pp. 220-223 More about this Journal
Abstract
In the course of screening tyrosinase inhibitory activity, total methanolic extract and EtOAc-soluble fraction of Smilax china leaves showed significant inhibitory activity. Further fractionation and isolation of the EtOAc-soluble fraction resulted in 12 phenolic compounds, which were identified as 4-hydroxybenzoic acid (1), 3,4-dihydroxybenzaldehyde (2), 3,4-dihydroxybenzoic acid (3), 3,4-dihydroxyacetophenone (4), 3-hydroxy-4-methoxy benzoic acid (5), trans-p-hydroxycinnamic acid (6), cis-p-hydroxycinnamic acid (7), trans-resveratrol (8), cis-resveratrol (9), dihydroresveratrol (10), moracin M (11) and kaempferol (12). Compounds 1-11 were first reported from this plant. Among the isolated compounds, compounds 2, 8, 9 and 12 showed strong inhibition on tyrosinase activity.
Keywords
Smilax china; Tyrosinase; Phenolic compounds; Kaempferol; Structure activity relationship;
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