Browse > Article

Ameliorative Effect of the Water Extract from Cirsium japonicum var. ussuriense Leaves on Blood Circulation in a Rat Model of Topical Ferric Chloride-Induced Carotid Artery Damage  

Kang, Hyun Ju (Imsil Herbal Medicine Association)
Kim, Hyeon Soo (Department of Healthcare & Science, Jeonju University)
Jeon, In Hwa (Ato Q&A Incorporation)
Mok, Ji Ye (Department of Healthcare & Science, Jeonju University)
Jeong, Seung-Il (Jeonju Biomaterials Institute)
Shim, Jae Suk (Imsil Herbal Medicine Association)
Jang, Seon Il (Department of Healthcare & Science, Jeonju University)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.2, 2013 , pp. 131-137 More about this Journal
Abstract
The present study has been undertaken to investigate the effect of the extract of Cirsium japonicum var. ussuriense leaves (CLE) on blood circulation in a rat model of topical ferric chloride ($FeCl_3$)-induced carotid artery damage. $FeCl_3$ treatment seriously damaged the carotid artery such as the walls of the artery, blood flow and inflammation. However, CLE administration has ameliorated blood circulation and suppressed vessel inflammation. CLE administration also has ameliorated the $FeCl_3$-induced artery tissue damage. Furthermore, CLE significantly suppressed the expression of adhesion molecules. These results suggest that CLE ameliorate blood circulation through suppress inflammatory mediator and adhesion molecule production.
Keywords
Cirsium japonicum var. ussuriense; Leaf extract; Blood circulation; Ameliorative effect; Anti-inflammation;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Xiromeritis, K., Dalainas, I., Stamatakos, M., Katsikas, V., Martinakis, V., Stamatelopoulos, K. and Psarros, V. (2012) Acute carotid stent thrombosis after carotid artery stenting. Eur. Rev. Med. Pharmacol. Sci. 16: 355-362.
2 Marques, M. A., Murad, F. F., Ristow, A. V., Silveira, P. R., Pinto, J. E., Gress, M. H., Massire, B., Cury, J. M. and Vescovi, A. (2010) Acute carotid occlusion and stroke due to antiphospholipid antibody syndrome: case report and literature review. Int. Angiol. 29: 380-384.
3 Xu, W., Wang, T. Y. and Becker, R. C. (2011) Hematologic diseases: from within the heart. Rev. Esp. Cardiol. 64: 606-613   DOI
4 Giannotti, G. and Landmesser, U. (2007) Endothelial dysfunction as an early sign of atherosclerosis. Herz. 32: 568-572   DOI
5 Kovanen, P. T. (2007) Mast cells: multipotent local effector cells in atherothrombosis. Immunol. Rev. 217: 105-122.   DOI   ScienceOn
6 Mancini, M. and Rubba, P. (2000) Ischemic cardiopathy: risk factors and their biological role. Ital. Heart J. 2: 17-22.
7 Aksu, K., Donmez, A. and Keser, G. (2012) Inflammationinduced thrombosis: mechanisms, disease associations and management. Curr. Pharm. Des. 18: 1478-1493.   DOI
8 Merten, M. and Thiagarajan, P. (2004) P-selectin in arterial thrombosis. Z. Kardiol. 93: 855-863.   DOI
9 Turun, S., Banghua, L., Yuan, Y., Zhenhui, L., Ying, N. and Jin, C. (2011) A systematic review of rivaroxaban versus enoxaparin in the prevention of venous thromboembolism after hip or knee replacement. Thromb. Res. 127: 525-534.   DOI   ScienceOn
10 Warner, T. D., Nylander, S. and Whatling, C. (2011) Antiplatelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy. Br. J. Clin. Pharmacol. 72: 619-633.   DOI   ScienceOn
11 Hassan, H. T. (2004) Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy. Leuk. Res. 28: 667-671.   DOI   ScienceOn
12 Jiang, R. W., Lau, K. M., Hon, P. M., Mak, T. C., Woo, K. S. and Fung, K. P. (2005) Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza. Curr. Med. Chem. 12: 237-246.   DOI   ScienceOn
13 Williams, M. J., Sutherland, W. H, McCormick, M. P., Yeoman, D. J. and de Jong, S. A. (2005) Aged garlic extract improves endothelial function in men with coronary artery disease. Phytother. Res. 19: 314-319.   DOI   ScienceOn
14 Lee, J. J., Yang, H., Yoo, Y. M., Hong, S. S., Lee, D., Lee, H. J., Lee, H. J., Myung, C. S., Choi, K. C. and Jeung, E. B. (2012) Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease. J. Atheroscler. Thromb. 19: 516-522   DOI   ScienceOn
15 Lee, S. J. (1996) Korean folk medicine. Seoul National University Press, Seoul. pp. 145-146.
16 Yun, T. K, Seo, H. C. (1994) CD Donguibogam. Yekangmoonhwasa, SoulbitChoseonmedia Corp.
17 Chung, C. C. (1993) Thistle as the useful plant resources. Korean Nat. Plant Preser. Soci. p. 372.
18 Lim, S.-S., Lee, J.-H. and Park, J.-C. (1997) Isolation of Flavone glycoside from Circium japonicum var. ussuriense and biological activity on the cardiovascular system. J. Korean Soc. Food Sci. Nutr. 26: 242-247.
19 Liu, S., Luo, X., Li, D., Zhang, J., Qui, D., Liu, W., She, L. and Yang, Z. (2006) Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int. Immunopharmacol. 6: 1389-1393.
20 Lee, H. K., Kim, J. S., Kim, N. Y., Kim, M. J., Park, S. U. and Yu, C. Y. (2003) Antioxidant, antimutagenicity and anticancer activities of extracts from Circium japonicum var. ussurience Kitamura. Korean J. Medicinal Crop Sci. 11: 53-61
21 Kim, S. J. and Kim, G. H. (2003) Identification for flavones in different parts of Cirsium japonicum. J. Food Sci. Nutr. 8: 330-335.   DOI   ScienceOn
22 Lee, M. K., Moon, H. C., Lee, J. H., Kim, J. D., Yu, C. Y. and Lee, H. Y. (2002) Screening of immune enhancing activities in medicinal herbs, Compositae. Korean J. Medicinal Crop Sci. 10: 51-57.
23 Park, J. C., Hur, J. M., Park, J. G., Kim, S. C., Park, J. R., Choi, S. H. and Choi, J. W. (2004) Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alchoholmetabolizing enzymes and lipid peroxidation in ethanoltreated rats. Phytother. 8: 19-24.
24 Mok, J. Y., Kang, H.-J., Cho, J.-K., Jeon, I. H., Kim, H. S., Park, J. M., Jeong, S.-I., Shim, J.-S. and Jang, S. I. (2011) Antioxidative and Anti-inflammatory Effects of Extracts from Different Organs of Cirsium japonicum var. ussuriense. Kor. J. Herbology. 26: 39-47.
25 Kang, H. J., Mok, J. Y., Cho, J. -K., Jeon, I. H., Kim, H. S., Park, J. M., Jeong, S.-I., Shim, J. -S. and Jang, S. I. (2012) Protective effects of leaf and flower extracts from Cirsium japonicum var. ussuriense on oxidative damage in normal human erythrocytes and plasma. Kor. J. Pharmacogn. 43: 66-71
26 Kurz, K. D., Main, B. W. and Sandusky, G. E. (1990) Rat model of arterial thrombosis induced by ferric chloride. Thromb. Res. 60: 269-280.   DOI   ScienceOn
27 Hirsh, J., Fuster, V., Ansell, J. and Halperin, J. L. (2003) American heart association; american college of cardiology foundation. American heart association/american college of cardiology foundation guide to warfarin therapy. Circulation. 107: 1692-1711.   DOI   ScienceOn
28 Welin, L., Wilhelmsen, L., Bjrnberg, A. and Oden, A. (2009) Aspirin increases mortality in diabetic patients without cardiovascular disease: a Swedish record linkage study. Pharmacoepidemiol. Drug Saf. 18: 1143-1149.   DOI   ScienceOn
29 Gmez-Outes, A., Surez-Gea, M. L., Calvo-Rojas, G, Lecumberri, R., Rocha, E., Pozo-Hernndez, C., Terleira-Fernndez, A. I. and Vargas-Castrilln, E. (2012) Discovery of anticoagulant drugs: a historical perspective. Curr. Drug Discov. Technol. 9: 83-104.   DOI
30 Honda, F., Imai, H., Ishikawa, M., Kubota, C., Shimizu, T., Fukunaga, M. and Saito, N. (2006) Cilostazol attenuates gray and white matter damage in a rodent model of focal cerebral ischemia. Stroke. 37: 223-228.   DOI   ScienceOn
31 Nishimura, S., Manabe, I., Nagasaki, M., Kakuta, S., Iwakura, Y., Takayama, N., Ooehara, J., Otsu, M., Kamiya, A., Petrich, B.G., Urano, T., Kadono, T., Sato, S., Aiba, A., Yamashita, H., Sugiura, S., Kadowaki, T., Nakauchi, H., Eto, K. and Nagai, R. (2012) In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood. 119: 45-56.   DOI
32 Chen, D. L., Chen, T. W., Chien, C. T. and Li, P. C. (2011) Intravenous low redox potential saline attenuates FeCl3- induced vascular dysfunction via downregulation of endothelial H2O2, CX3CL1, intercellular adhesion molecule-1, and p53 expression. Transl. Res. 157: 306-319.   DOI   ScienceOn