Browse > Article

Quantitative Analysis of Atractylenolides I and III in Atractylodes japonica  

Yun, Bo-Ra (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Weon, Jin Bae (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Lee, Bohyoung (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Lee, Jiwoo (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Eom, Min Rye (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Ma, Choong Je (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.1, 2013 , pp. 53-59 More about this Journal
Abstract
This study was conducted to determine the content of atractylenolides I and III in Atractylodes japonica. An established HPLC-DAD method was used to monitor contents of atractylenolides I and III in A. japonica obtained from Korea and China and compared with contents of A. macrocephala, A. chinensis, and A. lancea. Quantitative analysis of atractylenolides I and III was carried out on a Shiseido C18 column (S-5 ${\mu}m$, 4.6 mm I.D. ${\times}$ 250 mm) with gradient elution composed of acetonitile-water. The results show that the average content of atractylenolides I and III in A. japonica were 0.0954 and 0.1963%, respectively, and contents of A. lancea were higher than A. macrocephala, A. chinensis. In this study, we identified the differentiation of the quality of A. japonica from different species and collected locations and established content standard of atractylenolides I and III in A. japonica and this content standard was helpful to quality control of A. japonica.
Keywords
Atractylodes japonica; Atractylenolide I; Atractylenolide III; Monitoring; Quality control;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 윤성식, 정호영, 박상우, 김진미, 조충식, 김철중 (2011) 삼 령백출산가미방의 만성 신질환 환자 8례에 관한 증례 보고. 대한한방내과학회지 32: 465-472.
2 김남권, 오용열, 서은성, 이동효 (2010) 이명증에 대한 보중익기탕과 반하백출천마탕의 비용효과 분석 연구. 한방안이비인후피부과학회지 23: 260-269.
3 Lee, S. I. (1981) Studies on the diruretic action of oryeongsan and kami-oryeongsan. Kor. J. Pharmacogn. 12: 31-43.
4 Chang, Y.-H., Kim, C. T., Jung, M. H., Lim, Y.-H., Lee, S. H., Kang, S. J. (2007) Inhibition of melanogenesis by selina- 4(14),7(11)-dien-8-one isolated from Atractylodis Rhizoma Alba. Biol. Pharm. Bull. 30: 719-723.   DOI   ScienceOn
5 박성태, 이명수, 전병훈, 박기인, 오재민 (2011) 백출의 파골세포 분화에 미치는 영향. 동의생리병리학회지 25: 109-114
6 한정훈, 김진효, 김성건, 정성희, 김도훈, 김기은, 황완균 (2007) 백출 지상부의 항산화 성분. 약학회지 51: 88-95.
7 박찬성, 김동한 (2008) 황금, 산조인, 백출 추출물의 생리 활성. 대한본초학회 23:41-51.
8 이성옥, 서지희, 이정원, 유미영, 권지웅, 최상운, 강종성, 권대영, 김영균, 김영섭, 유시용 (2005) 백출 추출물의 암세포증식 저해 효과. 생약학회지 36: 201-204.
9 한윤경, 박용기 (2011) 백출이 streptozotocin 유발 당뇨흰쥐에서 췌장 및 신장에 미치는 영향. 대한본초학회 26: 23-30.
10 Nakai, Y., Kido, T., Hashimoto, K., Kase, Y., Sakakibara, I., Higuchi, M., Sasaki, H. (2003) Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying. J. Ethnopharmacol. 84: 51-55.   DOI   ScienceOn
11 Hikino, H., Hikino, Y., Yosioka, I. (1964) Studies on the constituents of Atractylodes. IX. Structure and autoxidation of atractylon. Chem. Pharm. Bull. 12: 755-760.   DOI   ScienceOn
12 Junichi, K., Akane, K., Toru, I., Akihito, T., Tatsuo, F., Susumu, I., Yoshiteru, I. (2003) Glycosides of Atractylodes japonica. Chem. Pharm. Bull. 51: 152-157.   DOI   ScienceOn
13 Konno, C., Suzuki, Y., Oishi, K., Munakata, E., Hikino, H. (1985) Isolation and hypoglycemic activity of atractans A, B and C, glycans of Atractylodes japonica Rhizomes1. Planta Med. 51: 102-103.   DOI   ScienceOn
14 Matsuda, H., Li, Y., Taniguchi, K., Yamahara, J., Tamai, Y. (1991) Imaging analysis of antiulcer action and the active constituent of Atractylodis rhizome. J. Pharm. Soc. Jpn. 111: 36-39.
15 Satoh, K., Nagai, F., Ushiyama, K., Kano, I. (1996) Specific inhibition of Na+,K(+)-ATPase activity by atractylon, a major component of byaku-jutsu, by interaction with enzyme in the E2 state. Biochem. Pharmacol. 51: 339-343.   DOI   ScienceOn
16 이제현, 김윤경, 홍선표, 김정숙 (2002) 백출과 창출의 기원에 대한 식물분류학적 연구. 한국한의학연구원논문집 8: 55-63.
17 원호영, 최창원, 김경수, 김경옥, 이동원, 김수연 (2006) 반하백출천마탕이 국소 뇌 허혈로 인한 치매 병태 백서에 미치는 영향. 동의신경정신과학회지 17: 61-73.