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Antioxidant Activity and Inhibition of MMP-1 Expression of Schizandrae fructus (Schizandra chinensis) Extract  

Park, Sung-Min (R&D Center, CoSeedBioParm Corporation)
Kim, Jin-Jun (R&D Center, Kolmar Korea CO., LTD.)
Jeong, Kwan-Young (R&D Center, Kolmar Korea CO., LTD.)
Han, Sang-Keun (R&D Center, Kolmar Korea CO., LTD.)
Jeong, Tae-Hwa (R&D Center, Kolmar Korea CO., LTD.)
Yun, Mi-Young (Department of Beauty Science, Kwangju Women's University)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.1, 2013 , pp. 47-52 More about this Journal
Abstract
We invesitagat the effects of antioxidant and suppression of MMP-1 in UV-irradiated human dermal fibroblasts (HDF) by schizandrin isolated from Schisandra chinensis. Ultrasonic technique was used to extract schizandrin from S. chinensis. The higher contents of schizandrin (6.34 mg/ml) in 70% EtOH extract obtained by ultrasonic treatment at 20 MHz for 2 h during 10 days. Schizandrin had antioxidant activities. Schizandrin (1-10 ${\mu}g/ml$) induced a significant dose-dependent decrease in the expression fo MMP-1 protein. These results suggest that schizandrin is a potential candidate for the prevention and treatment of skin aging.
Keywords
Schizandra chinensis; Schizandrin; Cosmetics; Anti-wrinkle; Metalloproteinase-1;
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