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Memory Enhancing Effect of Codonopsis lanceolata by High Hydrostatic Pressure Process and Fermentation  

Weon, Jin Bae (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Lee, Bohyoung (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Yun, Bo-Ra (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Lee, Jiwoo (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Lee, Hyeon Yong (Department of Teaics, Seowon University)
Park, Dong-Sik (Functional food & Nutrition Division, Department of Agrofood Resources)
Chung, Hee-Chul (Newtree CO., LTD.)
Chung, Jae Youn (Newtree CO., LTD.)
Ma, Choong Je (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.1, 2013 , pp. 41-46 More about this Journal
Abstract
Alzheimer's disease (AD), most common form of dementia is characterized that memory deficit and loss of cognitive function. The Codonopsis lanceolata (C.lanceolata) was treated by high hydrostatic pressure process and fermentation. This study was evaluated cognitive enhancing effect C.lanceolata extract by high hydrostatic pressure process and fermentation and compared with common C.lanceolata extract using Morris water maze and passive avoidance test. And their neuroprotective effect on glutamate induced oxidative stress in HT22 cell was investigated by MTT assay. High hydrostatic pressure process and fermented C.lanceolata extract (HFCE) and common C.lanceolata extract (CCE) (100 and 300 mg/kg) were administered to mice. Results showed HFCE enhanced cognitive function than CCE as shown by decrease in escape latency time. HFCE increased the latency time of the passive avoidance test compared to CCE. Furthermore, HFCE showed significant neuroprotective effect against glutamate cytotoxicity in HT22 cells. These results indicate that high hydrostatic pressure process and fermented more improve spatial cognitive ability of C. laanceolata.
Keywords
Codonopsis lanceolata; High hydrostatic pressure process; Fermentation; Cognitive enhancing effect; Neuroprotective effect;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Collerton, D. (1986) Cholinergic function and intellectual decline in Alzheimer's disease. Neurosci. 19: 1-28.   DOI   ScienceOn
2 Coyle, J. T. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695.   DOI   ScienceOn
3 Muphy, T. H., Miyamoto, M., Sastre, A., Schnaar, R. and Coyle, J. T. (1989) Glutamate toxicity in neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron. 2: 1547-1558.   DOI   ScienceOn
4 Park, S. J., Park, D. S., Lee, S. B., He, X., Ahn, J. H., Yoon, W. B. and Lee, H. Y. (2010) Enhancement of antioxidant activities of Codonopsis lanceolata and fermented Codonopsis lanceolata by ultra high pressure extraction. J. Korean Soc. Food Sci. Nutr. 39: 1898-1902.
5 Ebert, U. and Kirch, W. (1998) Scopolamine model of dementia: electroencephalogram findings and cognitive performance. Eur. J. Clin. Invest. 28: 944-949.   DOI   ScienceOn
6 Blokland, A. (1995) Acetylcholine: a neurotransmitter for learning and memory? Brain Res. Rev. 21: 285-300.   DOI   ScienceOn
7 Portelius, E., Zetterberg, H., Andreasson, U., Brinkmalm, G., Andereason, N., Wallin, A., Westman-Brinkmalm, A. and Blennow, K. (2006) An Alzheimer's disease-specific betaamyloid fragment signature in cerebrospinal fulid. Neurosci. Lett. 409: 229-237.
8 Citron, M. (2002) Alzheimer's disease: treatments in discovery and development. Nat. Neurosci. 5: 1055-1057.   DOI   ScienceOn
9 Bartus, R. T., Dean, R. L., Beer, D. and Lipa, A. S. (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408-417.   DOI
10 Dawson, G. R. and Iversen, S. D. (1993) The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory, Behav. Brain Res. 57: 143-153.   DOI   ScienceOn
11 Dastmalchi, K., Damien, D. H. J., Vuorela, H. and Hiltunen, R. (2007) Plants as potential sources of drug development against Alzheimer's disease. Int. J. Biomed. Pharmaceut. Sci. 1: 83-104.
12 Ushijima, M., Komoto, N., Sugizono, Y., Mizuno, I., Sumihiro, M., Ichikawa, M., Hayama, M., Kawahara, N., Nakane, T., Shirota, O., Sekita, S. and Kuroyanagi, M. (2008) Triterpene glycosides from the roots of Codonopsis lanceolata. Chem. Pharm. Bull. 56: 308-314.   DOI   ScienceOn
13 Li, J. P., Liang, Z. M. and Yuan, Z. (2007) Triterpenoid saponins and anti-inflammatory activity of Codonopsis lanceolata. Pharmazie. 62: 463-466.
14 Wang, L., Xu, M. L., Hu, J. H., Rasmussen, S. K. and Wang, M. H. (2011) Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells-- involvement of ROS generation and polyamine depletion. Food Chem. Toxicol. 49: 149-154.   DOI   ScienceOn
15 Ryu, H.- S. (2009) Effect of Codonopsis lanceolatae Extracts on mouse IL-2, IFN-, IL-10 cytokine production by peritoneal macrophage and the ratio of IFN-, IL-10 cytokine. Korean J. Food Nutr. 22: 69-74.
16 Han, C., Li, L., Piao, K., Shen, Y. and Piao, Y. (1999) Experimental study on anti-oxygen and promoting intelligence development of Codonopsis lanceolata in old mice. Zhong .Yao. Cai. 22:136-138.
17 Choi, W.- Y., Lee, C.- G., Seo, Y.- C., Song, C.- H., Lim, H.- W. and Lee, H.- Y. (2012) Effect of high pressure and steaming extraction processes on Ginsenosides Rg3 and Rh2 contents of cultured-root in wild Ginseng (Panax ginseng C. A. Meyer). Korean J. Med. Crop Sci. 20: 270-276.   DOI   ScienceOn
18 Jeong, M. H., Choi, W. Y., Seo, Y. C., Kang, H. Y. Choi, G. P. and Lee, H. Y. (2010) Anticancer activity of Acer mono Wood extracted by ultra high pressure extraction process. Korean J. Med. Crop Sci. 18: 157-167.
19 Park, M. R., Yoo, C., Chang, Y. N. and Ahn, B. Y. (2012) Change of total polyphenol content of fermented Gastrodia elata Blume and radical scavenging. Korean J. plant Res. 25: 379-386.   DOI   ScienceOn
20 Yang, H. J., Weon, J. B., Lee, B. and Ma, C. J. (2011) The alteration of components in the fermented Hwangryunhaedok- tang and its neuroprotective activity. Pharmacogn. Mag. 7:207-212.   DOI   ScienceOn
21 Morris, R. (1984) Developments of water-maze procedure for studying spatial learning in rats. J. Neurosci. Methods 11: 47-60   DOI   ScienceOn
22 Crapper, D. R. and DeBoni, U. (1978) Brain aging and Alzheimer's disease. Can. Psychiatr. Assoc. J. 23: 229-233.