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Free Radical Scavengers of Taxillus delavayi (Van Tiegh.) Danser.  

Lee, Chung Hak (College of Pharmacy, Woosuk University)
Ahn, Dalrae (College of Pharmacy, Woosuk University)
Cui, Xun (College of Pharmacy, Woosuk University)
Yang, Jae-Heon (Center for Healthcare Technology Development, Chonbuk National University)
Lee, Eun Byeol (College of Pharmacy, Woosuk University)
Xing, Ming Ming (College of Pharmacy, Woosuk University)
Tao, Chao (College of Pharmacy, Woosuk University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Cho, Chong Hyeon (Jeollabuk-do Agricultural Research and Extension Servieces)
Lee, Jae Hyeok (Dept. of Oriental Pharmaceutical Development, Nambu University)
Park, Jeong-Suk (Dept. of Alternative Medicine, Nambu University)
Kim, Dae Keun (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.4, 2012 , pp. 297-301 More about this Journal
Abstract
In the course of screening for antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH), a total extract of the twigs of Taxillus delavayi (Loranthaceae) was found to show potent radical scavenging activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of two phenolic compounds, catechin (1) and galloyl catechin (2), as active principles. Their structures were elucidated by spectroscopic studies. These two compounds showed the significant antioxidative effects on DPPH, and riboflavin- and xanthin-originated superoxide quenching activities. And these two compounds also showed strong nitric oxide radical scavenging effects. In riboflavin- and xanthin-originated superoxide quenching activities and nitric oxide radical scavenging effect, compound 2 showed better antioxidant activities than vitamin C.
Keywords
Taxillus delavayi; Loranthaceae; DPPH; Superoxide quenching activity; Radical scavenging effect;
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