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Establishment of Shelf-life of Ssanghwa-tang by Long-term Storage Test  

Seo, Chang-Seob (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine)
Kim, Jung-Hoon (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine)
Lim, Soon-Hee (The Institute of Life Science Research, Global Health Care Co. Ltd.)
Shin, Hyeun-Kyoo (Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.3, 2012 , pp. 257-264 More about this Journal
Abstract
The purpose of this study was to estimate the shelf-life of Ssanghwa-tang by long-term storage test. Experiments were conducted to evaluate the stability such as the selected physicochemical, pH, identification, heavy metal, microbiological experiment under a long-term storage test of Ssanghwa-tang. The significant change was not showed in pH, heavy metal, microbiological, identification test and quantitative analysis based on long-term storage test. The contents of albiflorin, paeoniflorin, cinnamic acid, liquiritin, and glycyrrhizin in long-term storage test were 66.8-93.1 ${\mu}g/mL$, 429.0-495.0 ${\mu}g/mL$, 3.8-4.4 ${\mu}g/mL$, 32.0-38.1 ${\mu}g/mL$, and 66.8-71.7 ${\mu}g/mL$, respectively. Shelf-lifes by 5 compounds about 3 lots at room temperature were predicted 21-37, 14-21, and 16-72 months, respectively. The suggested shelf-life would be helpful on the storage and distribution of herbal medicine.
Keywords
Shelf-life; Ssanghwa-tang; Long-term storage test; Herbal medicine;
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Times Cited By KSCI : 5  (Citation Analysis)
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