Browse > Article

Flavonoids Constituents of Duchesnea chrysantha  

Liu, Qing (College of Pharmacy, Chungbuk National University)
Ahn, Jong-Hoon (College of Pharmacy, Chungbuk National University)
Kim, Seon-Beom (College of Pharmacy, Chungbuk National University)
Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
Lee, Mi-Kyeong (College of Pharmacy, Chungbuk National University)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.3, 2012 , pp. 201-205 More about this Journal
Abstract
In the course of screening pancreatic lipase inhibitory activity, total methanolic extract and EtOAc-soluble fraction of Duchesnea chrysantha showed significant inhibitory activity. Further fractionation and isolation of the EtOAc-soluble fraction resulted in five compounds, which were identified as trans-tiliroside (1), isovitexin (2), kaempferol-8-O-${\beta}$-glucoside (3), kaempferol-3-O-${\beta}$-glucoside (4) and quercetin-3-O-${\beta}$-glucoside (5). All the five flavonoids derivatives were first reported from this plant but showed weak inhibitory effects on pancreatic lipase activity.
Keywords
Duchesnea chrysantha; Pancreatic lipase; Flavonoid; Trans-tiliroside; Obesity;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Brug, J. and Crawford, D. (2009) The obesity pandemic. Is it bad or worse? Eur. J. Public Health 19: 570-571.
2 Spielgelman, B. M. and Enerback, S. (2006) The adipocyte: a multifunctional cell. Cell Metab. 4: 425-429.   DOI   ScienceOn
3 Kopelman, P. G. (2000) Obesity as a medical problem. Nature 404: 635-638.
4 Lowe, M. E. (1994) Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion. Gastroenterology 107: 1524-1536.   DOI   ScienceOn
5 Ballinger, A. and Peikin, S.R. (2002) Orlistat: its current status as an anti-obesity drug. Eur. J. Pharmacol. 440: 109-117.   DOI   ScienceOn
6 Birari, R. B. and Bhutani, K. K. (2007) Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov. Today 12: 879-889.   DOI   ScienceOn
7 Yun, J. W. (2010) Possible anti-obesity therapeutics from nature. Phytochemistry 71: 1625-1641.   DOI   ScienceOn
8 배기환 (2000) 한국의 약용식물, 213, 교학사, 서울.
9 Yang, E. J., Lee, J. S., Yun, C. Y., Kim, J. H., Kim, J. S., Kim, D. H. and Kim, I. S. (2008) Inhibitory effects of Duchesnea chrysantha extract on ovalbumin-induced lung inflammation in mouse model of asthma. J. Ethnopharmacol. 118: 102-107.   DOI   ScienceOn
10 Lee, I. R. and Yang, M. Y. (1994) Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell. Arch. Pharm. Res. 17: 476-479.   DOI
11 Lee, J. S., Kim, I. S., Ryu, J. S., Kim, J. H., Kim, J. S., Kim, D. H. and Yun, C.Y. (2012) The inhibitory effect of Duchesnea chrysantha extract on the development of atopic dermatitis- like lesions by regulating IgE and cytokine production in Nc/Nga mice. Phytother Res. 26: 284-290.   DOI   ScienceOn
12 Lee, I. R., Wee, S. W. and Hang, Y. N. (1989) Studies on the pharmacological actions and biologically active components of Korean traditional medicines (VI). Tannins from Duchesnea indica. Kor. J. Pharmacogn. 20: 110-116.
13 Lee, I. R., Hahn, S. H., Han, Y. N. and Jeong, G. (1990) Studies on the pharmacological actions and biologically active components of Korean traditional medicines (VII). On the anticancer macromolecular substances from Duchesnea indica Herba. Kor. J. Pharmacogn. 21: 186-192.
14 Ahn, J. H., Liu, Q., Lee, C., Ahn, M. J., Yoo, H. S., Hwang, B. Y. and Lee, M. K. (2012) A new pancreatic lipase inhibitory from Broussonetia kanzinoki. Bioorg. Med. Chem. Lett. 22: 2760-2763.   DOI   ScienceOn
15 Hamerski, L., Bomm, M. D., Silva, D. H. S., Young, M. C. M., Furlan, M., Eberlin, M. N., Castro-Gamboa, I., Cavalheiro, A. J. and Bolzani, V. S. (2005) Phenylpropanoid glucosides from leaves of Coussarea hydrangeifolia (Rubiaceae) Phytochemistry 66: 1927-1932.   DOI   ScienceOn
16 Tsukamoto, S., Tomise, K., Aburatani, M., Onuki, H., Hirota, H., Ishiharajima, E. and Ohta, T. (2004) Isolation of cytochrome p450 inhibitors from strawberry fruit, Fragaria ananassa. J. Nat. Prod. 67: 1839-1841.   DOI   ScienceOn
17 Lin, C. N., Kuo, S. H., Chung, M. I., Ko, F. N. and Teng, C. M. (1997) A new flavone C-glycoside and antiplatelet and vasorelaxing flavones from Gentiana arisanensis. J. Nat. Prod. 60: 851-853.   DOI   ScienceOn
18 Choi, H. G., Jiang, Y., Park, S. H., Son, S. R., Na, M. K. and Lee, S. H. (2011) Constituents of flowers of Carthamus tinctorius L. and their antioxidant activity. Kor. J. Pharmacogn. 42: 110-116.
19 Yang, S., Park, S., Ahn, D., Yang, J. H., Cho, C. H., Hwang, Y. H., Park, J. H. and Kim, D. K. (2010) DPPH free radical scavenging effect of the aerial parts of Desmodium oldhami. Kor. J. Pharmacogn. 41: 180-184.
20 Oyama, K. and Kondo, T. (2004) Total synthesis of apigenin 7,4'-di-O-${\beta}$-glucopyranoside, a component of blue flower pigment of Salvia patens, and seven chiral analogues. Tetrahedron 60: 2025-2034.   DOI   ScienceOn
21 Kato, H., Li, W., Koike, M., Wang, Y. and Koike, K. (2010) Phenolic glycosides from Agrimonia pilosa. Phytochemistry 71: 1925-1929.   DOI   ScienceOn
22 Ninomiya, K., Matsuda, H., Kubo, J., Morikawa, T., Nishida, N. and Yoshikawa, M. (2007) Potent-anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside. Bioorg. Med. Chem. Lett. 17: 3059-3064.   DOI   ScienceOn
23 Qiao, W., Zhao, C., Qin, N., Zhai, H. Y. and Duan, H. Q. (2011) Identification of trans-tiliroside as active principle with anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects from Potentilla chinensis. J. Ethnopharmacol. 135: 515-521.   DOI   ScienceOn
24 Sala, A., Recio, M. C., Schinella, G. R., Manez, S., Giner, R. M., Cerda-Nicolas M. and Rosi, J. L. (2003) Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside. Eur. J. Pharmacol. 461: 53-61.   DOI   ScienceOn
25 Rao, Y. K., Fang, S. H., Tzeng, Y. M. (2005) Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-a and IL-12 in activated macrophages. Biol. Pharm. Bull. 28: 912-915.   DOI   ScienceOn
26 Matsuda, H., Ninomiya, K., Shimoda, H. and Yoshikawa, M. (2002) Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of riliroside and mechanisms of action. Bioorg. Med. Chem. 10: 707-712.   DOI   ScienceOn
27 Goto, T., Teraminami, A., Lee, J. Y., Ohyama, K., Funakoshi, K., Kim, Y. I., Hirai, S., Uemura, T., Yu, R., Takahashi, N. and Kawada, T. (2012) Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice. J. Nutr. Biochem. 23: 768-776.   DOI   ScienceOn