Browse > Article

Screening of Herbal Medicines for Phosphodiesterase 5 Inhibitor  

Lee, Keyong-Ho (Korea Prime Pharm)
Kim, Byeong-Soo (College of Industrial Sciences, Kongju National University)
Rhee, Ki-Hyeong (College of Industrial Sciences, Kongju National University)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.2, 2012 , pp. 184-191 More about this Journal
Abstract
The aim of this study was to explore the potent phosphodiesterase type 5 (PDE %) inhibitor from various herbal medicines for erectile dysfunctions. In this study, 61 herbal medicines, which were extracted with ethanol, have been investigated with PDE 5 assay using enzyme inhibitory activity on 22 species of herbal medicines. Of these, 5 species of herbal medicines, Cnidium monieri, Cuscuta chinensis, Epimedium koreanum, Morinda officinalis, and Tribulus terrestris were exhibited stronger inhibitory effect against phosphodiesterase 5 (PDE 5) among 61 species; Cnidium monieri ($IC_{50}=33.7{\mu}g/ml$), Cuscuta chinensis ($IC_{50}=65.7{\mu}g/ml$), Epimedium koreanum ($IC_{50}=90.3{\mu}g/ml$), Morinda officinalis ($IC_{50}=48.7{\mu}g/ml$) and Tribulus terrestris ($IC_{50}=32.5{\mu}g/ml$).
Keywords
Phosphodiesterase 5; Erectile dysfunctions; Herbal medicine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Oh, S. Y., Jun, H. J and, Kim, S. C. (2002) Changin trends in the treatment of erectile dysfunction in the era of oral sildenafil. Korean J. Urol. 43: 69-74.
2 최형기 (2002) 발기부전치료의 새로운 PDE5 (phosphodiesterase 5) 억제제들. 약물요법, 1050-1056, 출판사명, 지명기입요망.
3 Pantel, J., Williams, S. Y., Mi, D., Sebag, J., Corbin, J. D., Weaver, C. D. and Cone, R. D. (2011) Development of a high throughput screen for allosteric modulators of melanocortin- 4 receptor signaling using a real time cAMP assay. Eur. J. Pharmacol. 660: 139-147.   DOI   ScienceOn
4 Chen, C. Y., Chang, Y. H., Bau, D. T., Huang, H. J., Tsai, F. J., Tsai, C. H. and Chen, C. Y. (2009) Discovery of potent inhibitors for phosphodiesterase 5 by virtual screening and pharmacophore analysis. Acta Pharmacol. Sin. 30: 1186- 1194.   DOI   ScienceOn
5 Chen, C. Y. (2009) Computational screening and design of traditional Chinese medicine (TCM) to block phosphodiesterase-5. J. Mol. Graph. Model. 28: 261-269.   DOI   ScienceOn
6 Ho, C. C. and Tan, H. M. (2011) Rise of herbal and traditional medicine in erectile dysfunction management. Curr. Urol. Rep. 12: 470-478.   DOI   ScienceOn
7 Zhang, J., Li, Y., Sun, J., Liu, C. and Zhang, D. (2011) Synergistic or antagonistic effect of MTE plus TF or icariin from Epimedium koreanum on the proliferation and differentiation of primary osteoblasts in vitro. Biol. Trace Elem. Res. 143: 1746-1757.   DOI   ScienceOn
8 Zhang, W., Wang, Y., Yang, Z., Qiu, J., Ma, J., Zhao, Z. and Bao, T. (2011) Antioxidant treatment with quercetin ameliorates erectile dysfunction in streptozotocin-induced diabeticrats. J. Biosci. Bioeng. 112: 215-218.   DOI   ScienceOn
9 Zamble, A., Carpentier, M., Kandoussi, A., Sahpaz, S., Petrault, O., Ouk, T., Hennuyer, N., Fruchart, J.C., Staels, B., Bordet, R., Duriez, P., Bailleul, F. and Martin-Nizard, F. (2006) Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms. J. Cardiovasc. Pharmacol. 47: 599-608.   DOI   ScienceOn
10 Hnatyszyn, O., Moscatelli, V., Rondina, R., Costa, M., Arranz, C., Balaszczuk, A., Coussio, J. and Ferraro, G. (2004) Flavonoids from Achyrocline satureioides with relaxant effects on the smooth muscle of Guinea pig corpus cavernosum. Phytomedicine 11: 366-369.   DOI   ScienceOn
11 Stanislavov, R. and Nikolova, V. (2003) Treatment of erectile dysfunction with pycnogenol and L-arginine. J. Sex Marital Ther. 29: 207-213.   DOI   ScienceOn
12 Drewes, S. E., Horn, M. M., Munro, O. Q., Dhlamini, J. T., Meyer, J. J. and Rakuambo N.C. (2002) Pyrano-isoflavones with erectile- dysfunction activity from Eriosema kraussianum. Phytochemistry 59: 739-747.   DOI   ScienceOn
13 Boswell-Smith, V., Spina, D. and Page, C. P. (2006) Phosphodiesterase inhibitors. Br. J. Pharmacol. 147 Suppl 1: S252-257.
14 Ahn, B. O., Ko, K. H., Oh, T. Y., Cho, H., Kim, W. B., Lee, K. J., Cho, S. W. and Hahm, K. B. (2001) Efficacy of use of colonoscopy in dextran sulfate sodium induced ulcerative colitis in rats: the evaluation of the effects of antioxidant by colonoscopy. Int. J. Colorectal. Dis. 16: 174-181.   DOI   ScienceOn
15 Li, Y. F., Huang, Y., Amsdell, S. L., Xiao, L., O'Donnell, J. M. and Zhang, H. T. (2009) Antidepressan and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology 34: 2404-2419.   DOI   ScienceOn
16 Field, S. K. (2011) Roflumilast, a novel phosphodiesterase 4 inhibitor, for COPD patients with a history of exacerbations. Clin. Med. Insights Circ. Respir. Pulm. Med. 5: 57-70.
17 Cheung, Y. F., Kan, Z., Garrett-Engele, P., Gall, I., Murdoch, H., Baillie, G. S., Camargo, L. M., Johnson, J. M., Houslay, M. D. and Castle J. C. (2007) PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform- specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6). J. Pharmacol. Exp. Ther. 322: 600-609.   DOI   ScienceOn
18 White, J. B., Thompson, W. J. and Pittler, S. J. (2004) Characterization of 3',5' cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: absence of functional PDE6. Mol. Vis. 10: 738-749.
19 Smith, S. J., Cieslinski, L. B., Newton, R., Donnelly, L. E., Fenwick, P. S., Nicholson, A. G., Barnes, P. J., Barnette M. S. and Giembycz, M. A. (2004) Discovery of BRL 50481 [3- (N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol. Pharmacol. 66: 1679-1689.   DOI   ScienceOn
20 Jeremy, J. Y., Ballard, S. A., Naylor, A. M., Miller, M. A. and Angelini, G. D. (1997) Effects of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro. Br. J. Urol. 79: 958-963.   DOI
21 Giuliano, F. (2002) PDE5 inhibition in erectile dysfunction : a overview. Eur. Heart. J. 4: H7-12.   DOI
22 Carson, C. C., Burnett, A. L., Levine, L. A. and Nehra, A. (2002) The efficacy of sildenafil citrate (Viagra) in clinical populations: an update. Urology 60: 12-27.
23 본초학 (2002) 한국생약교수협의회. 아카데미서적, 서울.
24 Braun, M., Wassmer, G., Klotz, T., Reifenrath, B., Mathers, M. and Engelmann, U. (2000) Epidemiology of erectile dysfunction: results of the 'Cologne Male Survey'. Int. J. Impot. Res. 12: 305-311.   DOI   ScienceOn
25 Francis, S. H., Turko, I. V. and Corbin, J. D. (2001) Cyclic nucleotide phosphodiesterases: relating structure and function. Prog. Nucleic Acid Res. Mol. Biol. 65: 1-52.
26 Houslay, M. D. (2001) PDE4 cAMP-specific phosphodiesterases. Prog. Nucleic Acid Res. Mol. Biol. 69: 249-315.